The chemistry of the jaborandi alkaloids / by H.A.D. Jowett. The pharamacology of the jaborandi alkaloids / by C.R.Marshall. Remarks on extractum jaborandi liquidum (B.P.) / by H.A.D. Jowett and C.R. Marshall.

  • Jowett, H. A. D. (Hooper Albert Dickinson)
Date:
1900?]
Catalogue details

Licence: In copyright

Credit: The chemistry of the jaborandi alkaloids / by H.A.D. Jowett. The pharamacology of the jaborandi alkaloids / by C.R.Marshall. Remarks on extractum jaborandi liquidum (B.P.) / by H.A.D. Jowett and C.R. Marshall. Source: Wellcome Collection.

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    The supply of A was exhausted before the experiments were finished, and consequently another sample, A2. which proved to be similar in com¬ position, was obtained from the same source. Owing to the small quanti¬ ties at our disposal, the comparatively slight amounts of alkaloids, and the presence of resin, the assay could not be expected to give accurate results. The “ total alkaloid” invariably contains resin, and this inter¬ feres with the crystallisation of the alkaloidal salt. A and A2 may have contained a small amount of pilocarpine or its allies (o.oi to 0.02 per cent ), and B, which contained a large quantity of resin, may have contained more than that given. This is what we found physiologically. When injected into the circulation of animals these preparations, although crude and containing 45 per cent, of alcohol, were found to be fairly well borne. Fig. 1 shows the effect of the three samples on the blood pressure of a small rabbit. It is the first experiment made. The animal had been chloroformed, the right carotid artery joined to the manometer, a cannula introduced into the right external jugular vein, and the right vagus ligatured, cut, and stimulated several times before the injections were commenced. Extractum jaborandi liquidum A (1 c.cm.) un¬ diluted was first injected. c !c c m.Ext.Jab.Liq. 60I.A. *-___*■ . ri [For description see next pope.'] The blood pressure, which was rather low, fell somewhat, and the heart instead of beating 17 in 5 seconds only beat 12! Afterwards the blood pressure rose considerably above its pievious height, and then fell slightly. The vagus was also
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