Further evidence on the homogeneity of the resistance to the implantation of malignant new growths / by E.F. Bashford and B.R.G. Russell ; [communicated by J. Rose Bradford].

  • Bashford, Ernest Francis, 1873-
Date:
1910
Catalogue details

Licence: In copyright

Credit: Further evidence on the homogeneity of the resistance to the implantation of malignant new growths / by E.F. Bashford and B.R.G. Russell ; [communicated by J. Rose Bradford]. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    [Reprinted from the Proceedings of the Boyal Society, B. Vol. 82] ' V Further Evidence on the Homogeneity of the Resistance to the Implantation of Malignant New Growths. E. F. Bashford, M.D., and B. B. G. Bussell, M.D., Imperial Cancer Besearch Fund. (Communicated by Prof. J. Bose Bradford, Sec. B.S. Beceived January 17,— Bead February 3, 1910.) This paper is based mainly on a study of the processes at the site of implantation of a malignant new growth when a secondary implantation is practised on mice already bearing transplanted tumours. New evidence will be adduced supporting the view that concomitantly with the establishment of such tumours, an active resistance may be induced by the absorption of tumour tissue. When a secondary inoculation fails, this failure is due to an active resistance to the cancer cells introduced, similar to that induced in normal animals by the absorption of tumour tissue or normal tissue of the same species. The process consists essentially in the cancer cells failing to elicit the specific connective tissue and vascular scaffolding necessary to their establishing themselves and growing into a tumour. In order to simplify still further prevailing conceptions of the process of immunity to cancer, we shall record corresponding observations on rats where the primary inoculation of a mouse carcinoma has been followed by a secondary inoculation of mouse tumour. In the First Scientific Beport of the Imperial Cancer Besearch Fund (March, 1904) it was stated “ in the light of the phenomena of immunity, it is interesting to note that it is possible to obtain multiple tumours from trans-