Ergotoxine and some other constituents of ergot / by George Barger and H.H. Dale.

  • George Barger
Date:
[1907]
Catalogue details

Licence: In copyright

Credit: Ergotoxine and some other constituents of ergot / by George Barger and H.H. Dale. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

    3/62
    ERGOTOXINE AND SOME OTHER CONSTITUENTS OF ERGOT By G. BARGER, M.A. (Cantab), D.Sc. (.Lond.), and H. H. DALE, M.A., B.C. (Cantab). From the Wellcome Physiological Research Laboratories, Herne Hill, London, S.E. (Received April 3rd, 1907) CONTENTS 1. Introductory ........ 240 2. Historical ......... 241 3. Ergotoxine— (a) Chemical ....... 245 (b) Physiological ....... 246 4. The Relation of Ergotoxine to other Ergot Alkaloids . . . 270 5. The presence of Ergotoxine in supposed active principles of a non-Alkaloidal nature— (a) in Jacobj’s Preparations ...... 278 (b) in Robert’s Sphacelinic Acid . . . . .283 6. The Ergot Preparations of the British Pharmacopoeia . . . 286 7. Vahlen’s Clavin ........ 288 8. Summary and Conclusion . . . . . . .296 9. Bibliography ........ 298 In papers already published by us (partly in conjunction with F. H. Carr) we have described certain physiological effects produced by ergot preparations and the isolation and chemical properties of the alkaloid ergotoxine, to which these effects are due. In the present paper1 we propose to describe more completely the general physiological action of this alkaloid, and to discuss, in the light of our earlier experiments, its occurrence in the numerous substances which have from time to time been described as active principles of ergot. 1. For the chemical experiments G. Barger is responsible, for the physiological H. H. Dale.
    digitised image 1
    digitised image 2
    digitised image 3