A modification of diphtheria antitoxin / by A.T. Glenny.

  • Glenny, A. T.
Date:
[1913?]
Catalogue details

Licence: Public Domain Mark

Credit: A modification of diphtheria antitoxin / by A.T. Glenny. Source: Wellcome Collection.

    8/12 page 66
    The cases quoted so far are those of very old sera kept under special conditions until the unit value (judged by the L-f- dose) has fallen very low. This modification of antitoxin, although most fre¬ quently observed in such old sera, is not confined to them alone. TABLE IV. Tests upon samples of blood from guinea-pig T 3. 7. 12 actively immunised to diphtheria toxin. Date of removal of Volume of Volume of sample of blood blood toxin Local reaction Death 21 Aug. 1/7 c.c. 0*01 C.C. Very large swelling Death in 4 days 25 Sept. >> 0-01 Large swelling Survival 1 Oct. y y 0-01 Small swelling yy 4 „ yy 0-02 Very large swelling Death in 4 days 21 „ 1/70 c.c. 0-01 yy yy „ 54 days 23 „ yy 0-02 No swelling Survival 23 „ yy 0*05 Large swelling Death in 8 days ' 25 „ yy 0*05 No swelling Survival a X o -4-3 25 „ yy 0-1 y y Death in 19 days 28 „ yy 0-1 y y Survival ^ T3 *-4-3 fl 28 „ yy 0-15 y y Death in 16 days •2 a c3 «4-l o 28 „ yy 0-2 Small swelling >> 3 ,, aS'S 30 „ yy 0-2 No swelling M 6 ,, ^ ga S £ o • rH -4-> CJ qzl 1 Nov. yy 0-1 yy Survival (paralysis) 8 o' 1 „ yy 0*15 y y Death in 13 days ) Ph • *-H <-c o 5 „ yy 0*15 yy 5> 3 ,, 6 „ yy 0-1 yy „ 20 „ „ yy 0*12 Small swelling 4 yy ^ yy 21 „ yy 0-08 Large swelling 4 yy ^ yy 2 „ yy 0-05 y y 5 yy J yy Among routine tests upon the unit value of fresh antitoxic serum from horses, instances have been noted in which the local reactions caused by an L+ mixture were smaller than those usually observed. More frequently this phenomenon has occurred when testing the blood of guinea-pigs actively immunised to diphtheria toxin. These tests were made during an investigation still in progress by Dr H. J. Siid- mersen and myself. Table IV records the most marked instance that has occurred. At frequent intervals blood was withdrawn from the animal, mixed with diphtheria toxin, and injected subcutaneously into other guinea-pigs. For a time these tests followed the normal course, producing local reactions; then for a certain period marked modification of the antitoxin occurred ; later the test resumed its normal course. It
    digitised image 1
    digitised image 2
    digitised image 3