The relation between the teeth, and certain diseases of the skin and mucous membrane / by W. Knowsley Sibley.
- Sibley, Walter K. (Walter Knowsley), 1862-
- Date:
- 1911
Licence: In copyright
Credit: The relation between the teeth, and certain diseases of the skin and mucous membrane / by W. Knowsley Sibley. Source: Wellcome Collection.
Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.
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![10 million or 100 million of organisms, according to the nature of the growth; the vaccine is then ready for use. An injection is given about every ten days, the dose being usually gradually increased accord- ing to the reaction obtained. Each case must, however, be treated on its merits, and no hard and fast rule can be laid down, either as to the most suitable dose of vaccine, or the length of period between the injections—in other words, every patient has his, or her, own individual peculiarities of reaction, which must lie dealt with accordingly. I will now describe one or two. examples of vaccine injections :— A case of erythema bnllosuni in a single woman, aged 31, who had never been seriously ill, and always considered herself strong and liealthy. She had an erythematous eruption accompanied by superficial liullse eight years previously, affecting the neck and face only. The condition lasted for three months and she recovered. The present attack had lasted for sixteen months when she first came under my observation on February 22 of this year. The eruption commenced on the back, then on the neck, and upper part of the eliest, then the forearms, and afterwards the legs. All these regions were extensively covered by erythematous patches in various stages of huJlous formation, and many areas of pigmentation, and some superficial scarring fiom i)revious lesions. The extremities were cold and somewhat cyanosed. There was no olivious cardiac lesion. There was considerable pyorrhoea alveolaris, affecting all the lower incisors, and the left first l)icuspid. T!ie growth oljtained from the pus was a mixture of streptococci, staphylococci, and slendei' hacilli, and from this a vaccine was px’epared of such a strength tliat 1 c.c. contained 10 million organisms. On March 2 an injection of 5 million was given, and the next day a fresh lesion appeared in the lumlxar region, tliere not having been a new lesion for some time previously. On March 9 another 5 million were injected, and this was followed hy a fresh lesion on the dorsum of the right foot. Other injections were given on March 20 (7 million) and IMarch 30 (lO million) ; fresh lesions followed each injection. 1 also treated the ])yorrhoe,a directly by short exposures to X-rays, and gave her an antiseptic month-wash, but no internal treatment was given. On Ajxril 13, as a control experiment, she had an injection of aqua destillata. She has remained free from fresh lesions since, so to-day she had 5 million vaccine organisms injected. The condition of the ])yorrhoea has already considerably improved, and she continues well in herself. A man, aged 44, had suffered for many months from very troublesome chronic urticaria all over the body, which was very rebellious to various treatments, and be also had some acne rosacea on the face. A considerable amount of pyorrhoea was present, affecting most of tlie teeth on the left side of his mouth, and the lower lateral incisor, and the canine on the right side. A pure streptococcus culture was obtained from the i>us and a vaccine prepared; an injection of 5 million was given on March 9, on March 16, 10 million were injected, and on April 13, 5 million more,](https://iiif.wellcomecollection.org/image/b2241874x_0018.jp2/full/800%2C/0/default.jpg)
