Serums, vaccines and toxines in treatment and diagnosis / by Wm. Cecil Bosanquet ... and John W.H. Eyre.
- William Cecil Bosanquet
- Date:
- 1909
Licence: In copyright
Credit: Serums, vaccines and toxines in treatment and diagnosis / by Wm. Cecil Bosanquet ... and John W.H. Eyre. Source: Wellcome Collection.
Provider: This material has been provided by The University of Leeds Library. The original may be consulted at The University of Leeds Library.
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![less (2 to 2.] cc.); children receive still smaller amounts. The vaccine is given by subcutaneous injection into the ami. The administration is followed by redness and swelling at the seat of inoculation, and constitutional symptoms in the form of rise of temperature and feeling of illness. The latter pass oft' in about twenty-four hours, but the patient should spend the first day after the treatment at rest, not resuming his ordinary avocations till the second day. Results Of inoculation.—Haffkine considers that pro- tection against plague is produced rapidly—at the end of twenty-four hours. In view of the facts ascertained by Wright with regard to antityphoid inoculation, it seems likely that there may be at first a period of increased susceptibility to infection, and this has been asserted by Calmette. Ban- nermann, however, denies that this is the case, and considers that the injection does not aggravate an attack, if made during the incubation-piriod. Of the figures given by Haffkine as to the results obtained with his inoculations, we may quote those relating to the village of Undhera.1 Among 64 uninoculated persons there were 27 cases of plague, and 26 of these proved fatal; while among 71 inocu- lated persons—members of the same families as the former and living under exactly the same conditions—there were 8 cases, 3 of which were fatal. The deaths among the un- inoculated thus exceeded those among the inoculated by 89-65 per cent. LeumanS records that of 1,173 mill-hands, 1,010 were inoculated twice: among these there were 22 deaths (2-11 per cent.); of 58 inoculated once, 8 died (13-79 per cent) • of 75 not inoculated, 20 died (26 6 per cent.). Bannermann states that in a total of 6,000 cases the mortality among the inoculated was 43-5 percent., while among the uninoculated it was 73-7 per cent. 1 lancet, 1899, i. 1097. lal QUlld b)' MiSS Slau^ter, Johns Hopkins Eosp. Bull., Nov. i.J\)oj ]). o07. '](https://iiif.wellcomecollection.org/image/b21507594_0181.jp2/full/800%2C/0/default.jpg)
