Chemical examination of the root of Ipomoea orizabensis / by Frederick B. Power and Harold Rogerson.

  • Frederick Belding Power
Date:
1912
Catalogue details

Licence: In copyright

Credit: Chemical examination of the root of Ipomoea orizabensis / by Frederick B. Power and Harold Rogerson. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    This product amounted to 327 grams. When further dried it could be reduced to a light brown powder, which, however, became viscid on exposure to the air. It was freely soluble in water, and did not reduce Fchling’s solution until after boiling with a dilute mineral acid. The total amount of the above-mentioned syrupy product was dissolved in alcohol, mixed with purified sawdust, and the thor- oughly dried mixture extracted successively in a Soxhlet apparatus with light petroleum, ether, chloroform, ethyl acetate, and alcohol. The light petroleum removed nothing, and, after extracting with the three succeeding solvents, nothing further was removed by the alcohol. Ether and Chloroform Extracts of the Hydrolysed Resin (II). These extracts were dark-coloured, viscid masses, amounting to 25 and 2 grams respectively. They were sparingly soluble in water, and after heating with a 5 per cent, solution of sulphuric acid in aqueous alcohol, nothing definite could be isolated. The liquids obtained by this treatment reduced Fehling’s solution, but no osazone could be prepared from them. Ethyl Acetate Extract of the Hydrolysed Resin (II). This was a colourless, semi-crystalline mass, amounting to 300 grams. When thoroughly dried, it could be reduced to a fine, white powder, which was not hygroscopic. It was only sparingly soluble in ethyl acetate, even when hot, but readily soluble in alcohol, acetone, and water. The aqueous solution was optically active, and a determination of its specific rotatory power gave the following result : 0'7750, made up to 20 c.c. with distilled water, gave oD — 2°55/ in a 2-dcm. tube, whence [a]D — 37‘62°. A quantity (200 grams) of the above-described product was heated for about three hours in a reflux apparatus with ten times its weight of aqueous 5 per cent, sulphuric acid, and the liquid then distilled in a current of steam. The distillate, which amounted to 3 litres, was first extracted with ether, when a small amount of an oil was removed, which partly solidified. The oily portion gave the colour reaction for furfuraldehyde, whilst the solid substance, which separated from ethyl acetate in laminae melting at 44°, appeared to consist of methyl jalapinolate, a compound which was obtained in somewhat larger amount from the non-volatile products of the acid hydrolysis. The aqueous distillate, after extraction