Internal secretion and the ductless glands / by Swale Vincent ; with a preface by E. A. Schäfer.

  • Swale Vincent
Date:
1912
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Licence: In copyright

Credit: Internal secretion and the ductless glands / by Swale Vincent ; with a preface by E. A. Schäfer. Source: Wellcome Collection.

Provider: This material has been provided by UCL Library Services. The original may be consulted at UCL (University College London)

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    sixty-nine hours instead of thirty-four ! As pointed out by Biedl (25), the duration of life of nephrectomized animals is extremely variable. According to his own experiences in some cases dogs and rabbits may survive as long as five or six days after extirpation of both kidneys, while in other cases they may die in thirty-six hours. Again, the incidence and course of the symptoms of uraemia in such animals is no criterion of their actual condition. It frequently happens that nephrectomized animals show no characteristic symp- toms for two, three, or even four days, and then suddenly succumb. Others, on the other hand, on the day after the operation, suffer from vomiting and dyspnoea, then either recover or remain in a chronic condition of uraemia for several days [Biedl (25)]. Such experiments are of little value as demonstrating an internal secretion on the part of the kidney, and still less as pointing to the treatment of nephritis in man by means of kidney extracts. However, Capitain (50) reports a case of severe ursemia cured by subcutaneous injections of kidney extracts. Teissier and Frenkel (363) state that injection of kidney extracts relieved nephritis, and Formanek and Eiselt (HO) report good results in five cases of chronic nephritis after treatment with kidney extracts by the mouth. Rautenberg (306) performed a series of experiments upon rabbits, in which he tied one (the left) ureter. The ligature was removed at the end of three weeks, and later the healthy (right) kidney was extirpated. The animal lived with the diseased kidney for one and a half to two and a half years, and suffered from albuminuria, high blood-pressure, and other signs of nephritis. At the autopsy there was found to be extensive artero-sclerosis. Lindemann (215) found that guinea-pigs, after having received injections of rabbit-kidney emulsions, furnished a serum which was very toxic io rabbits, giving rise to albu- minuria and uraemia. The injection of this nephrolytic serum provokes symptoms precisely similar to those in- duced by true kidney poisons. Here we have the formation of certain specific substances formed in the blood under the influences of the processes of absorption of the renal substance injected, and these are the substances which affect the kidney. Schiiltze (332) could not observe the
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