The depressor effect of adrenalin on arterial pressure / by W.B. Cannon and Henry Lyman.
- Walter Bradford Cannon
- Date:
- [1913?]
Licence: Public Domain Mark
Credit: The depressor effect of adrenalin on arterial pressure / by W.B. Cannon and Henry Lyman. Source: Wellcome Collection.
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![tration.2, In 1900 Moore and Purington reported that extracts of adrenal medulla of the ox caused, when given in exceedingly minute doses, a fall of blood pressure in the dog. Larger doses resulted in the typical rise of pressure. They suggested that the extract might contain two substances, the depressor substance stronger because effective at greater dilution; but they also admitted that a single substance might be present having opposite ef- fects according to its dosage.’ These observations have been variously explained away. Pari found in a few instances an increased flow through the perfused kid- neys and hind legs of dogs when a weak adrenalin solu- tion kept for some time was added to the circulating fluid, but this did not occur a fa if the adrenalin solution was Ficure 1.— A, blood-pressure changes during stim- fresh. He expressed the ulation of left splanchnic nerves two and one- belief, therefore, that adre- quarter minutes. B, the same, after tying nalin. even in very smal] atteries of the splanchnic area; stimulation, half ) ° a minute. B doses, never causes (in rab- bits) a fall of arterial pressure, and he suggested that the results obtained by Moore and Purington were due to chemical changes in the dilute extracts used by them.* Vincent has intimated that in these and in other instances of a depressor constituent of the adrenal glands ° the common power of tissue extracts to lower blood pres- sure may be invoked in explanation. Thus doubt is thrown on > BARDIER and FRANKEL: Journal de physiologie et pathologie générale, 1899, - i, p. 960. * Moore and Purincton: Archiv fiir die gesammte Physiologie, 1900; bax, p. 483. * Part: Archives italiennes de biologie, 1906, xlvi, p. 218. ° See GURBER: Sitzungsberichte der physikalisch-medicinischen Mang” Wiirzburg, 1897, iv, p. 54; Hunt: this Journal, 1900, iii, p. xviii. 6 Vincent: Internal secretion and the ductless glands, London, 1912, p. 174.](https://iiif.wellcomecollection.org/image/b3343122x_0004.jp2/full/800%2C/0/default.jpg)
