A case of chronic tuberculosis of the nose, tonsils, larynx, trachea, and main bronchi (sclerous lupus (?) without external manifestations), producing stenosis of the trachea and bronchi / by Thomas Whipham and Sheridan Delépine, read March 8, 1889.

  • Whipham, Thomas.
Date:
[1889]
Catalogue details

Licence: Public Domain Mark

Credit: A case of chronic tuberculosis of the nose, tonsils, larynx, trachea, and main bronchi (sclerous lupus (?) without external manifestations), producing stenosis of the trachea and bronchi / by Thomas Whipham and Sheridan Delépine, read March 8, 1889. Source: Wellcome Collection.

Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.

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    logy between the deep layers of the rete Malpighii and ciliated epitheha—a fact which I have tried to establish a few years ago and to which I intend to refer in some further paper based on this case—S. D.~| This epithelium is very thick at the places where the mucous membrane is thinnest namely at the four angles of the trapezoid lumen above de- scribed. There it sends processes into the subjacent mucosa which forms a number of papilliform projections between these epithelial digitations. Where the mucous membrane is thicker the epithelium is on the contrary thinner In some regions it is very thin, at places it is raised from the surface of the mucosa by subepithelial effusion of blood or of coagu- lated lymph. It is even absent over a few small areee. In the mucosa and sub mucosa we have already noticed a very great alteration of structure, and an entire absence of mucous glands. We have also directed attention to the con- siderable difference of thickness that exists between the various parts; this thickness varies between one twelfth and one fourth of an inch (after hardening). [It is probable that during life greater differences must have existed, owing to the temporary swellings that must have resulted from the conges- tion, effusions, or haemorrhages which can be noticed in various parts of the specimen.] The structure of these membranes is not entirely the same in the thick and in the thin parts. In the thick parts there is generally a greater amount of lymphoid-or granulation tissue under the epithelium, and also a greater number of patches of cellular infiltration in the deeper parts, than is found in those parts where the membrane is thin. In the regions where the mucosa and submucosa form a thin layer, there is on the contrary a greater amount of rather dense and cicatricial-looking tissue. In the region where the mucosa and submucosa form a thick layer, the parts intervening between the cellular patches have an areolar arraugement; but the intercellular sub- stance, instead of having the appearance of wavy bundles of fine fibrils, has a very transparent and homogeneous look and is evidently in a state of hyaline degeneration. In some places the homogeneous intercellular substance forms a close network with one or two cells only in each mesh, and there the modified tissue looks more as if it had i*esulted from the transformation of lymphoid tissue, the alteration resulting from hyaline degeneration and swelling of the reticulum. The changes observable in the cartilaginous rings, the
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