Iodol, a new antiseptic : odourless and without poisonous properties, a substitute for iodoform : German patent no. 35,130 / sole makers Kalle & Co.

  • Kalle & Co.
Date:
[1886]
Catalogue details

Licence: Public Domain Mark

Credit: Iodol, a new antiseptic : odourless and without poisonous properties, a substitute for iodoform : German patent no. 35,130 / sole makers Kalle & Co. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    loclol was employed in oubstance, or suspended in glycerine, or it was used as an ointment made up with vaseline ; in addition, alcoholic solutions of lodol diluted with glycerine were also employed, since lodol is quite insol- uble in water. In venereal affections (chancres, adenitis, and periadenitis), lodol was used with the best results. The venereal sore having been washed with water, and carefully dried, was sprinkled over with lodol powder, and covered with silk protective ; if the chancre was large and very purulent, Brun’s wool was also employed ; this dressing was repeated every twenty-four hours. The following obser- vations deserve being called attention to :—After the dressing had been renewed from four to six times, the base of the chancre commenced to granulate, and the edges showed a tendency to cicatrise ; no fresh ulcera- tions, nor any adenitis in the inguinal region ever appeared, and even commencing inflammation of the lymphatic glands (in two cases) subsided without any special treatment. In patients who came with wounds which had large openings,with thinned, undermined, and blue edges, the free incisions Avhich are recommended in such cases could be avoided, and the surface of the sore simply sprinkled with lodol powder. In twenty-four hours a change was noticeable in the character and quantity of the secretion. The ulcer was cleansed with Brun’s wool, and after the dressing had been renewed three or four times, it commenced to granulate, and showed a tendency to rapid cicatrisation. In six cases of inflammation round the glands in the inguinal region, which had large openings, and in which the glands lay exposed, a rapid healing was effected without ever employing any of those operative pro- cedures which otherwise appear necessary in such obstinate affections. If the patient had not been subjected to any treatment before, we pro- ceeded as follows ;—With a tenotomy knife a small puncture was made, and the pus slowly evacuated through the small aperture, then with the aid of a Pravaz’s syringe, 2, 4, or 6 grammes of the alcoholic lodol solution,* according to the size of the cavity, were injected. As a rule the small opening closed too quickly, so that it had to be again opened with a sound, and the operation repeated. On the average, after six applications perfect healing was effected—i.e.^ in a period which is very much shorter than that which is otherwise neces- sary in similar cases. From the numerous observations which we have made as to the influence of lodol on extensive ulcers, we are able to give the various results in different forms of ulcerations. In ulcers where there is a very marked necrobiosis, the good effect of lodol is very remarkable—the foul smell disappears, the secretion diminishes, and the ulcer changes in a short time to a healthy granulating woucd. In atonic ulcers also the result was likewise favourable, and even after two applications a distinct improvement was to be observed. On the other hand, lodol was quite ineffectual in sloughing ulcers where there were marked sloughs ; in these cases we were obliged to discontinue its use, since not only did no improvement ensue, but the disease extended. The cause of this was, I believe, that the lodol in such cases is washed away by the fluids which are secreted in such quantity, and that in employ- ing alcoholic solutions the lodol is precipitated and then carried away. Since we were convinced, from very numerous observations, that lodol in a high degree favoured the growth of granulations, we have extended its use to various forms of lupus, and to chronic fungus disease of joints. The lodol treatment was applied to a patch of lupus on the outer aspect of the thigh of a girl, who also suffered from lupus hypertrophicus of the nose and cheek. lodol solution was injected into the subcutaneous tissue * The solution which we ])iefeiTecl consisted of lodol, 1 gramme ; alcohol, 16 grammes ; and glycerine, 24 grammes. This solution has a faintly yellow colour, and must be preserved in coloured bottles, since it decomposes (after a time) somewhat, if exposed to the light.