On some physiological actions of ergot / by H.H. Dale.

  • Henry Hallett Dale
Date:
[1906?]
Catalogue details

Licence: Public Domain Mark

Credit: On some physiological actions of ergot / by H.H. Dale. Source: Wellcome Collection.

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    pressure of 11 cm. water. Remnant of bladder exhibits rhythmical con¬ tractions, causing spirts of fluid through relaxed urethra. 1.49. 50 mgms. sodium chrysotoxin. B-p. rises from 56—72 mm. and falls again to 56 mm. Urethral sphincter now opens at 10 cm. water. 1.55. Stimulate hypogastrics : coil at 8 cm. Base of bladder contracts slightly, raising pressure to 12 cm., at which pressure water escapes through urethra, and continues to do so until pressure falls to 9 cm. There is obviously no contraction of the sphincter. 2.9. Stimulate hypogastrics. Coil at 75. No contraction of urethral sphincter, which again opens at 9 cm. 2.13. 2 c.c. nmnr adrenaline by jugular vein. B-p. falls from 90 mm. to 76 mm., remains depressed for 1 min. and then rises to reach 100 mm., 2 min. from injection. Urethral sphincter unaffected, opening at 10 cm. 2.18. Stimulation of hypogastrics, coil at 4 cm. No effect. Urethra becomes pervious at 10 cm. pressure. 2.23. 5 c.c. TTJUTnr adrenaline by the jugular vein. B-p. rises from 68—94 mm., the rise being apparently due to augmentation and acceleration of the heart-beat. Urethra unaffected, being pervious at 8 cm. pressure. It is clear that ergot in large doses annuls the motor response of the urethral sphincter to stimulation of the hypogastric nerves and to adrenaline. To stimulation of the pelvic nerves, or of the sacral roots, the bladder responds after ergot, as before, by complete and sustained contraction. (2) The ferret. The experiment was performed at Cambridge by Mr T. R. Elliott, and a full description of the result is given in his paper on the action of adrenaline1. We found that the motor effect of the hypogastric nerves and of adrenaline on the fundus of the bladder was changed, by 30 mgms. of chrysotoxin, into a purely inhibitor response to adrenaline, and a predominant inhibition with preliminary motor phase with stimulation of the hypogastrics. The motor effect evoked by electrical excitation of the nerves was, therefore, as in other cases, more resistant to the paralysis than that of adrenaline. Nicotine still caused the usual contraction, showing that the motor supply by the pelvic nerves was, as elsewhere, not paralysed. 8. The Pilo-motor Muscles. In my preliminary account it was stated that the pilo-motor effect of stimulating sympathetic nerves was not affected by chrysotoxin. The statement was made on the basis of an observation made at the end of an experiment, about an hour after a sufficient dose of chrysotoxin had beeu administered to reverse the effect of adrenaline on the blood-
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