The present aspect of the doctrine of cellular pathology : a lecture delivered at an evening meeting of the Royal College of Surgeons of Edinburgh, 27th February 1863 / by William Turner.

  • William Turner
Date:
1863
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Credit: The present aspect of the doctrine of cellular pathology : a lecture delivered at an evening meeting of the Royal College of Surgeons of Edinburgh, 27th February 1863 / by William Turner. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    tovy and ulcerative processes in it are due to the foimation of masses of nucleated cells within the cartilage corpuscles. By the persistence of this proliferating process, alteration and destruction of the wall of tlie cartilage corpuscle and the intercellular substance is occa- sioned. Dr Kedfem, however, expressed doubts, whether from these proliferating cartilage cells, pus corpuscles could be formed. But more recent researches ^ would appear to have demonstrated that, in purulent inflammations of joints, the pus-corpuscles may take their rise not only through changes in the synovial membrane, but through endogenous multiplication in the cartilage-cells themselves. ddj In Bone.—If a bone, in wliich the processes of ulceration and suppuration are going on, be microscopically examined, it may be seen that, in addition to the softening due to the removal of the earthy matter, otlier textural changes have set in. The Haversian canals have become dilated by the absorption and removal of their osseous walls, so that adjacent canals are thrown together and spaces and cavities are produced in the texture. At the same time these cavities become filled with a cellular growth—the granulation substance—from the free sm-face of which pus-corpuscles are thrown off f the immediate cause of the removal and absorption of the bone, and the formation of the spaces and cavities being the develop- ment of the cellular growth. But these changes are not confined to the production of a cellular mass in the Haversian canals; for alterations may be observed in the lacunas and canaliculi of the intermediate osseous texture. Minute drops of fat in the first instance appear in them, and, as this form of degeneration increases, the lacunte and canaliculi, owing to the softening and absorption of the intervening substance, gradually widen out, until at length several adjacent spaces are thrown together. In this manner, that perforated worm-eaten appearance is produced which is so charac- teristic of a carious bone.^ But along with this destruction of the osseous substance, a growth of cells in the enlarged spaces now occurs. These cells would appear to arise in one or other of two ways, either by the multiplication of the original nuclei of the bone lacunge,* or by the extension into the spaces of granulation-cells with accompanying bloodvessels, either from the periosteum, medullary membrane, or Haversian canals.* From these granula- tion-cells pus-cells may proceed in the usual manner. 4:ih, In Muscles,—In inquiring into the effects of iiTitants upon, and the mode of formation of pus in muscles, we shall experience perhaps somewhat greater difficulties in deciding upon the source ^ C. 0. Weber, VirchoVs Archiv, vol. xiii. p. 79 ; Fbrster, Atlas, pi. xxxiii. fig. 1, p. 65; Barwell, on Diseases of the Joints, 1861. Goodsir, op. cit., pp. 15, 71. ' Von Bibra, Annalen der Chemie und Pharm., vol. Ivii. p. 356, 1846; C. 0. Weber, Virchow's Archiv, vol. xv. * Virchow, Lecture 18; Fbrster, Atlas, taf. xxxi. fie. 6, taf. xxxiv. fie. 4 Bar^vell, p. 238. ^ » Billroth, Beitriige, p. 51; C. 0. Weber, op. cit. B
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