Lobsters, lymph and histamine-liberation / by W.D.M. Paton.

  • William Paton
Date:
1959
Catalogue details

Licence: In copyright

Credit: Lobsters, lymph and histamine-liberation / by W.D.M. Paton. Source: Wellcome Collection.

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    remarkable capacity to destroy histamine. In one sample as much as 80 [Jig. of histamine/hr./ml. lymph was destroyed at room tem¬ perature. In two experiments, tests were made as to whether lym- phagogues caused any change in the output of histaminase in the lymph. But no consistent change was found, apart from the increase in total output associated with increased lymph flow. Fig. 6. Cat, chloralose. Record of blood pressure, lymph flow, and time (minutes). Response to 100 /^g. Compound 48/80; intravenous injection Experiments with Other Substances The results just described showed that histamine-liberation and lymphagogue action are closely associated, and allow one to con¬ clude that it is histamine released from the tissues which causes the enhanced lymph flow. The opportunity was taken, however, to examine the actions on lymph flow of other substances capable of altering the blood pressure. The action of histamine has already been described. It was found, as would be expected, that mepyramine (1 mg.) given intra¬ venously before an injection of 20 [xg. histamine could almost abolish its lymphagogue effect at the same time as attenuating the depressor response. Acetylcholine, in doses producing a similar fall in blood pressure to that produced by histamine, was less effective, sometimes producing a few extra drops of lymph, sometimes reducing the flow a little. Hexamethonium, in a dose of 1-4 mg./kg., which produced a sustained fall in blood pressure, also had little significant action.
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