The treatment of sarcoma and carcinoma by injections of mixed toxins / by C. Mansell Moullin.

  • Mansell-Moullin, C. W. (Charles William), 1851-1940
Date:
1898
Catalogue details

Licence: Public Domain Mark

Credit: The treatment of sarcoma and carcinoma by injections of mixed toxins / by C. Mansell Moullin. Source: Wellcome Collection.

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    In six some sloughing took place. In two (an epithelioma and an endothelioma) the whole tumour sloughed out. One patient with carcinoma of the breast, who was in such a state of marasmus that her death was expected daily, improved considerably for a time, and put on weight. In another (carcinoma of the ovary) the cedema of the legs disappeared, and one or two others were apparently benefited, but only for a time. Freidrich concludes that the toxins have no specific effect whatever, and that the changes the tumours sometimes undergo are merely the expression of the cumulative action of a number of injurious influences working together. Campanini, // PoHclinico, July i, 1895. Sarcoma of Nasopharynx. An injection of | ccm. into the tumour was followed by a rigor, very high temperature, drowsiness, headache and tinnitus. This continued for ten hours. At the same time there was suppression of urine with intense thirst. The next day a second smaller injection was followed by even more alarming symptoms. After this experience an attempt was made to attenuate the toxins by ^dilution and exposure to high temperature. This attenuated toxin was injected on thirty occasions in the course of a month, the dose being progressively increased. The tumour continued to grow, and a part that was re- moved for microscopic examination showed no sign of any retrogressive change. A negative result was also obtained in a case of sarcoma of the breast. Gotham Bacon, Trans. Amer, Otological Society^ 1895. Sarcoma of Neck. The growth made its first appearance below the left ear, and extended in a very little while from the mastoid to the angle of the jaw and the middle of the sternomastoid. The left tonsil was also involved. Mixed toxins were injected into the tumour, apparently checking its growth and setting up local suppuration. The patient gradually sank, death being caused immediately by arterial haemorrhage from the tonsil.
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