Two cases of metastatic carcinoma of the choroid / by G. E. de Schweinitz.

  • George Edmund de Schweinitz
Date:
[1898]
Catalogue details

Licence: Public Domain Mark

Credit: Two cases of metastatic carcinoma of the choroid / by G. E. de Schweinitz. Source: Wellcome Collection.

Provider: This material has been provided by UCL Library Services. The original may be consulted at UCL (University College London)

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    eye, 2J millimeters in thickness and 12 millimeters in diameter at its broadest part. Its surface was brown, its center grayish- yellow, and, as before stated, it merged gradually at its sides and ends into the surrounding choroid, from which at no point it was sharply separated. (See Fig. i.) Serial microscopic sections cut by Dr. J. Button Steele from the other half furnish the following histological details: Serial microscopic sections cut by Dr. J. Dutton Steele from the growth begins and curves quickly upward for six millimeters, and then slopes downward for another six millimeters imtil it meets the normal choroid on the other side, being bounded above by the lamina vitrea and attached retinal pigment epithelium and below by the sclera. This mass, therefore, occupies the entire width of the choroid. It is composed of epithelial cells, rather spheroidal in shape and with large nuclei, here and there col- lections of small round cells which are early stages of necrotic foci, some pigment granules and spicules, and a moderate amount of stroma. Toward the bottom of the growth there is a tendency for the carcinoma cells to arrange themselves in long tubules separated by a faint stromal tissue which contains pigment particles. The appearance suggests vessels filled with cancer ele- ments, but is no doubt caused by the cells traveling along the connective tissue septa being deposited in the spaces. A similar appearance is noted by Lagrange. Toward the center of the growth and above the alveolar arrangement is more marked and the individual alveoli larger and broader. In the region of the chorio-capillaris some remnant of the original choroidal structure still remains and vessels plugged with cancer cells are readily dis- tinguished. The necrotic foci, also noted by Mitvalsky, have selected no special portion of the growth for their appearance. In some sections large thin-walled blood vessels, packed with blood corpuscles, pass through the sclera and run through the growth. Cancer cells, however, were not found amonsf the white and red blood corpuscles which plug their caliber, as Schultze did in his specimen. The optic nerve, retina, and remaining parts
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