Further observations on the endemic occurrence of carcinoma and on the inoculability of tumors / by Leo Loeb.

  • Leo Loeb
Date:
1907
Catalogue details

Licence: In copyright

Credit: Further observations on the endemic occurrence of carcinoma and on the inoculability of tumors / by Leo Loeb. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    pressed together; some of these cells were in mitotic division, otherwise no mitosis could be seen. At places where the cells were pressed together, the alveolar character was no longer well pronounced. The tumor tissue can penetrate deeply into the neighboring tissue. In the fat, which surrounds the tumor, the blood capillaries are well visible and in the neighborhood of the bloodvessels we see canals lined with high cells and with a colloid material in the centre. The alveoli of this tissue have a somewhat larger lumen than could be seen in the former tumors. Some areas of necrosis are present. January 19 seventeen mice were inoculated with this tumor. Two days later one inoculated mouse died. In the centre of the nodule the section shows necrosis. In the periphery living tumor cells are present with well-preserved alveoli which are perhaps a little shrunken. Four and one-half to five days after the transplantation seven tumor mice died, probably as a result of exposure to cold. The transplanted pieces were examined microscopically. No. 1 was mostly necrotic. At the margin, tumor alveoli were present which were well pre- served but somewhat shrunken. No. 2 shows the same picture. In some peripheral alveoli vesicular nuclei are well preserved. No. 3 shows the same. Especially noticeable is the fact that some of the transplanted alveoli, which were on all sides surrounded by connective tissue, were better preserved than some of the more peripheral alveoli. No. 4 shows, likewise, at the margin, alveoli which are. well preserved and only a little shrunken. In No. 5 the same condition is found. No. 6 is almost entirely necrotic. At the margin a few shrunken alveoli are present. No. 7 is entirely necrotic. The second tumor of mouse 5, which was a little ulcerated, shows in the whole the same structure as the first one. There are, however, more glandular ducts present in the connective tissue which separates the tumor lobules. The tumor lobules themselves are composed of large or small alveoli which contain a colloid mass in the centre. A number of mitoses are present in the tumor cells. Where
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