Four cases of congenital acholuric (so-called 'haemolytic') jaundice in one family / by F. Parkes Weber and G. Dorner.

  • Frederick Parkes Weber
Date:
[1910]
Catalogue details

Licence: In copyright

Credit: Four cases of congenital acholuric (so-called 'haemolytic') jaundice in one family / by F. Parkes Weber and G. Dorner. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

    5/20 (page 5)
    any clubbing oE the fingers. In all the cases, nnless other- wise stated, the various examinations were carried out by Dr. Dorner. Family history.—The father (B) of the other three patients tells us that he is one of a family of 15 children, eight of whom are still living, and that he is the only jaundiced one out of all the 15. His father (A.), however, was jaundiced all his life, sometimes looking very yellow, sometimes less so. He died at the age of 70 years as a result of ulceration of the leg. The paternal grandfather and grandmother of the man (B) are said not to have been jaundiced. Of B’s •ten children (six living, four dead) only three—namely, our above-mentioned three patients—inherited the jaundice. Of these three, the married daughter (C 1), the eldest of his children, has had herself four children, one of whom is said to have been yellow and to have died (“anaemia”) when 9 months old. In the accompanying genealogical table the italic letters indicate the affected members. M. stands for male, F. for female. >1. = F. M. (jl) = 1 F. 1 1 1 i 1 1 1 M. M. P. P. M. M. Jf. (B) = F. ]P. 1 1 1 1 M. M. P. nil. li. 1 1 M. P. 1 1 1 1 M. = P. M. M. M. 1 i P. M. 1 1 F. P. 1 M. 1 P. 1 (cl) D. D. L. D. V. L. (c2) (c3) L. 1 1 1 M. M. Miscarriage <Ij. V. at 6 at third weeks. month. M.U) D. at 9 months. ill. z., aged 16 months. We confess that we are not quite satisfied as to the correct ness of this family history, and should not be surprised to find that some of the brothers and sisters of B showed slight remittent or intermittent jaundice and a certain degree of splenomegaly. The jaundice.—This symptom, which appears to have been congenital in the four patients, is as well marked in the skin of the body and the mucous membrane of the mouth as in the ocular conjunctiva. At present it is least noticeable in the boy (C 3), and very distinct, though not very deep, in his two sisters (C1 and C 2),“ and in their father (B). The degree of yellowness varies occasionally from time to time, and is apparently deeper when they catch cold. The father (B) 22 When C 2 was seen on Jan. 3rd, 1910, the jaundice had almost completely disappeared.