On the artificial production of tubercle in the lower animals : a lecture delivered at the Royal College of Physicians, May 15, 1868 / by Wilson Fox.
- Fox, Wilson.
- Date:
- 1868
Licence: Public Domain Mark
Credit: On the artificial production of tubercle in the lower animals : a lecture delivered at the Royal College of Physicians, May 15, 1868 / by Wilson Fox. Source: Wellcome Collection.
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![clriecl-up debris of fattily degenerated material, ratlier than true puriform cells. The most common effect by far is the production of this cheesy matter under the skin. It is usually encapsuled; and sometimes there are two or three such masses, distinct from one another, or they may be more numerous, and may, together with the granulations next to be described, be found at considerable distances from the site of the inoculation. Thus in o]ie instance they extended two-thirds of the length of the spinal column, and caused death through paralysis consequent on their pressure producing erosion ol the bodies of two vertebrae, and subsequent softening of the spinal cord. In another case I found a rib similarly injured, but in neither of these instances was there any distinct tubercular change in the l)one. The capsule of these masses is firm, semi-transparent, almost lardaceous in appearance; it passes insensibly into the surrounding tissue. In addition, however, to these cheesy changes, another set of appearances are seen around the seat of injury. These are small granulations, varying in size from a poppy-seed, or even smaller, to that of a hemp-seed, which are irregularly scattered for a variable area in tlie suljcutaneous tissue. They are sometimes semi-transparent throughout; sometimes yellow and opaque throughout ; sometimes yellow in the centre, with a soni-transparent margin. Larger masses, of the size of a pea, are sometimes also found, apparenth^ presenting intermediate gradations between these and the larger cheesy masses : for they are cheesy in some parts, and indurated in others ; and they present a striking reseml}lance to the naked eye, and also under the microscope, to the changed lymphatic glands. These larger granulations are most commonly found near the seat of injury. The smaller granidations are often scattered on the outside of the capsules of the larger cheesy masses ; but they may extend to great distances beyond this, sometimes in lines and rows, sometimes in scattered circles, and in little groups. They often reach up to the neigh- bouring lymphatic glands, and are grouped in masses of varia1)le size around these (Plate I. fig. (5). In addition to these, cords of induration are seen extending, at variable depths and for variable distances, tlirougli the subcutaneous and muscular tissues. The cords are firm and semi-transparent, like gristle ; but their central portions are often cheesy. Sometimes they form varicose dilatations, reacliing up to the lymphatic glands. Sometimes cords extend through the lymphatic glands into the surrounding tissues: whether from or to the gland, it is difficult to say (Plate I. fig. 7). The cords are not constant, nor are the granulations, but the frequency with whicli they occur is very considerable. The granulations have not been](https://iiif.wellcomecollection.org/image/b20393246_0025.jp2/full/800%2C/0/default.jpg)
