Progress in medical genetics. Volume 4 / edited by Arthur G. Steinberg and Alexander G. Bearn.

Date:
1965
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: Progress in medical genetics. Volume 4 / edited by Arthur G. Steinberg and Alexander G. Bearn. Source: Wellcome Collection.

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    Chapter 1 Disorders of the Thymus and Other Lymphoid Tissues Raymond D. A. Peterson Established Investigator American Heart Association Max D. Cooper Postdoctoral Research Fellow U. S. Public Health Service and Robert A. Good American Legion Memorial Heart Research Professor of Pediatrics and Microbiology It has become increasingly evident over the last several years that immunologic deficiency states, autoimmune diseases, and lymphoid malignancies are interrelated pathogenetically: two or more of these conditions often occur simultaneously in a single patient and, in addi¬ tion, a predisposition to these disturbances exists in some families. Even more recently, as some of these problems have been taken into the laboratory, evidence has been brought forward suggesting that common disturbances of the thymus and other lymphoid tissues may underlie all three, both as they occur clinically and as they are observed in ex¬ perimental animals. It is the purpose of this review to bring together some of the widely scattered clinical and experimental evidence supporting this hypothesis. This task is facilitated by the recent growth in our knowledge concern¬ ing the lymphoid tissue. The latter is both the effector of the immune From the Pediatric Research Laboratories of the Variety Club Heart Hospital, University of Minnesota, Minneapolis. Aided by grants from the American Heart Association, American Cancer Society, The National Foundation and the U. S. Public Health Service ( HE-02085, AI- 00798, NB-02042). 1
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