On the difference in the results obtained after inoculation of tumors into the individual in which the tumor had developed spontaneously, and into other individuals of the same species / Leo Loeb and Samuel Leopold.

  • Leo Loeb
Date:
1907
Catalogue details

Licence: In copyright

Credit: On the difference in the results obtained after inoculation of tumors into the individual in which the tumor had developed spontaneously, and into other individuals of the same species / Leo Loeb and Samuel Leopold. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    Microscopical Examination. I. Pieces of original tumor not transplanted : i. Portions of ulcerated tumor taken out October 25, 1906. The tumor consists of numerous areas of prolifera- tion, showing connective tissue and epithelial changes; some consist entirely, or almost entirely, of proliferating connective tissue, with transitions from the connective tissue, rich in spindle cells, to hyaline connective tissue. In other areas transitions are occurring in the following manner: (1) the glandular tubules become larger, and are filled with colloid material; (2) the arrangement of the tubules becomes more irregular, and the connective tissue around the tubules increases and shows hyaline, myxoid, and cartilaginous changes. Some of these areas are surrounded by a con- nective tissue capsule, at many places glandular tissue is found that resembles normal mammary gland, but in which, here and there, transitions into adenomatous tumor structure can be seen. Some of the peculiarities of the tumor will be indicated in the description of the following pieces: Area A: A small area is present in which the glandular epithelium shows just beginning transitions into the abnor- mal. Slight dilatation of the tubules, containing small masses of colloid material. Area B consists of gland tubules which are cystic and contain colloid masses in the center. Between the epithelial structures are large masses of connective tissue which are very cellular in character. The latter show hyaline and, in places, myxoid changes. In the connective tissue we find colloid masses which may perhaps represent the remains of necrotic glandular structures. Into the dilated ducts, intra- canalicular growth is taking place, the connective tissue matrix of the ingrowth being supplied by myxomatous tissue. In some of the narrower tubules isolated cells carrying yellow pigment are found. Area C : In another area the cystic dilatation is absent and the structure resembles the normal mammary gland. The areas B and C are separated from each other by a connective tissue capsule.
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