On the uniformity of the pancreatic mechanism in vertebra / by W.M. Bayliss and E.H. Starling.

  • William Bayliss
Date:
[1903?]
Catalogue details

Licence: Public Domain Mark

Credit: On the uniformity of the pancreatic mechanism in vertebra / by W.M. Bayliss and E.H. Starling. Source: Wellcome Collection.

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    2. In those animals in whom we could not conveniently examine the secretion of pancreatic juice we confined ourselves to extracting the mucous membrane of the upper part of the intestine with acid, and testing this extract on the dog or other animal for the presence of secretin. We felt that we were justified in assuming the identity of the pancreatic mechanism in these animals with that in the dog, when we found that the animal from which the preparation was derived was a matter of indifference and that a secretin solution, which would produce a flow of pancreatic secretion in the dog, would also produce a flow in the cat, rabbit, monkey, or frog. We have so far as possible examined representatives of all the vertebrate classes, and need only mention very shortly the distinguishing features of the pancreatic mechanism in each case. Mammals. Of this class of animals we have investigated the flow of pancreatic juice in the monkey, dog, cat, and rabbit. We have moreover tested, for the presence of secretin, acid decoctions of the intestinal mucous membrane from the same four animals as well as from man, ox, sheep, pig, squirrel, and new-born kitten. From all these animals an active secretin solution was obtained which produced a flow Fig. 4. Pancreatic secretion of cat. Effect of injecting 5¢.c. of secretin solution from dog’s gut. Blood-pressure zero raised 15 mm. of juice in any of the above four animals. In all cases the acid decoction of mucous membrane contains also a depressor substance, although the extent of the depressor effect varies in different animals. In the cat
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