A contribution to our knowledge of the physiological action of antipyrin / by Rayner D. Batten and T.J. Bokenham.

  • Batten, Rayner Derry.
Date:
[1889]
Catalogue details

Licence: Public Domain Mark

Credit: A contribution to our knowledge of the physiological action of antipyrin / by Rayner D. Batten and T.J. Bokenham. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    [Reprinted for the Author from t^e British Mepical Jourkal, June 1,1889.] M22 JUL 89j| A CONTEIBUTIQN TO OIJ§ ^KNOWLEDGE OF THE PHYSIOLOGICAL ACTION OF ANTIPYRIN. By RATNEE D. BATTEN, M.D., B.S.Lond., AND T. J. BOKENHAM, L.S.A.Lond. CFrom the Laboratory of Dr. Lauder Brunton.) The subject of the physiological action of antipyrin was originally taken up by us in order to find out in what manner the drug might act in migraine and kindred diseases. The true pathology of these disorders being uncertain, the subject was, of course, a complex one, and we had no little difficulty in deciding on a defi- nite plan of research. Most physicians have, however, observed that the attacks are often accompanied by an alteration in the tone of the vascular walls—namely, an irregular contraction or spasm of portions of one of the temporal arteries, and probably of others less superficial. We thought, therefore, that here might be a clue to the action of the drug, which has been observed to abolish this symptom. To test this view it was suggested by Dr, Lauder Brunton that we might obtain some information by re- peating Nothnagel's experiment of locally stimulating the exposed intestine of an animal by means of a crystal of sodium salt, this producing, under normal circumstances, a distant peristaltic con- traction towards the duodenum, as well as a local annular con- striction at the point of stimulation. Dingram illustrat ing the effect of BtimiilatinR the intestine of an animal with a sodium salt; A before, B after the injection of antipyrin. The arrow points towards the duodenum. * the point of application of the sodium salt.