The menstruation and ovulation of Macacus rhesus : with observations on the changes undergone by the discharged follicle. Pt. II / by Walter Heape ; [communicated by M. Foster].
- Heape, Walter, 1855-1929.
- Date:
- 1897
Licence: Public Domain Mark
Credit: The menstruation and ovulation of Macacus rhesus : with observations on the changes undergone by the discharged follicle. Pt. II / by Walter Heape ; [communicated by M. Foster]. Source: Wellcome Collection.
Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.
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![mucosa is somewhat thicker than it is in S. enteUus, and that the protoplasmic network of the stroma is more granular and is denser, and the g’lands more numerous and more branched than are these structures in the latter animal. In xl/i rhesus as in S. entellus, there is an absence of any connective tissue frame- work in the stroma ; we have, in fact, here, an essentially primitive tissue capable of extensive and rapid growth, and of transformation into other and more specialised tissues. The uterine and glandular epithelium, the glands devoid of a definite sheath, and the arrangement of the musculature, are all the same as are seen in S. entellus. A. Period of Rest. Stage 1.—-The nuclei of the stroma at this stage are more densely packed in the lower portion of the mucosa than they are in the superficial part; in the latter situation a loose tissue exists, held together by a network of delicate protoplasmic processes. I have observed no fibrils in the stroma of M. rhesus. B. Period of Growth. Stage II.—There is a great increase in the number of the nuclei of the stroma, by means of amitotic division, in the upper third of the mucosa. The layer becomes in this part very densely crowded with nuclei, which, owing to the restraining pressure of the epithelium above, become elongated and flattened ; they continue to exhibit great activity in division and growth. Thus hyperplasia occurs. The rapidity -with which division goes on may be judged of by the proportion of very small nuclei present; they have their origin from the products of the first division of the stroma nuclei, and are in much larger proportion than the parent kind in many parts of the growing sti'oma layer. Two methods of division of the nucleus occur, namely division into two and fragmentation. The elongated nuclei of the growing stroma become constricted and divide into two, they are constantly to be seen in various stages of this [>rocess (fig. 1, Plate 1). Division by fragmentation in the case of the nuclei of the stroma, I laid some stress U])on in my former paper (No. 8), but was unable to demonstrate, to my own satis- faction, the actual separation and isolation of the various portions of the fragmented nucleus. The same difliculty of demonstration occurs also in M. rhesus. Owing to the crowding together of the nuclei into what is almost a compact mass, and owing to the continuous network of protoplasm, at this stage becoming practically a solid layer without meshes and without connecting processes, I have found it impossible to prove satisfactorily the origin of separate nuclei by fragmentation. Fig. 2 will serve to show the nature of the difficulty. This drawing is made with Reichert’s one-fifteenth immersion lens and Zeiss’ No. 4 eye-piece, and it is, as nearly as I can make it, exactly similar to the actual specimen, the nuclei are very small and the scanty protoplasmic matrix is entirely devoid of cell outlines. The group of nuclei marked a, in which three nuclei are indicated still attached the one to the other, I interpret to be a nucleus undergoing fragmentation, while the groups of nuclei](https://iiif.wellcomecollection.org/image/b22392701_0016.jp2/full/800%2C/0/default.jpg)
