Gelsemium : a study that embodies the recent work of L. E. Sayre together with fragments of a paper read by him before the American Pharmaceutical Association, Richmond, Virginia, 1910.

  • Sayre, Lucius E. (Lucius Elmer), 1847-1925
Date:
1911
Catalogue details

Licence: Public Domain Mark

Credit: Gelsemium : a study that embodies the recent work of L. E. Sayre together with fragments of a paper read by him before the American Pharmaceutical Association, Richmond, Virginia, 1910. Source: Wellcome Collection.

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    10.40 A. M. Injected 0.2 Ce. of the above solution. 10.55 A. M. Heart rate 60. 11.10 A.M. Heart rate 54. 11.15 A. M. Heart rate 49. 11.30 A.M. Heart rate 40. 11.30 A. M. Injected 0.4 Cc. of the solution. 11.45 A.M. Heart rate 30. 12.00 M. Heart rate 28. 12.40 P.M. Heart rate 26. 1.05 P.M. Heart rate 28. 1.10 P.M. Injected 0.5 Ce. 1.40.P> Me VHeartarates 1057 71.520 Pee Leartwaterce ails bene Heart rate 6. 2.20,P. M. Heart rate 5. 2.40 P.M. Heart ceased to beat. To determine relative toxicity: Four frogs of about equal weight—weights from 30 to 35 Gm.— were taken: EXPERIMENT 1. = = a = = = = = < < < < 04 py cy < g g g 8 g g g s Ss S = = a 8 o oo re re re Lama = Prep lacnct 0.7 Ce. | Normal | 0.5 Cc. | Very weak Dead. eb Mok mce OTCes Nearly | 0.5 Ce. Weak. Very Very weak.|Very weak. Dead. normal weak. IL fooace 0.7 Ce. Nearly |0.5 Ce. |} Excited. Ver Very weak. Dead. normal weak. EeLep aa 0.7 Ce. Quite 0.5 Ce. Dead. depressed. EXPERIMENT 2. <4 <4 < < = A ae < < i=) S i) S S i i=) > = — oO Ss oO S S S S Ss oO So re Lom! —N an) © [o.6} Oo re Comal ec ce re rc Prep. 1.0.1 Ce. | Normal. | 0.1 Ce. | Depressed.| 0.1 Ce. | Depressed. Dead. Prep. 2./0.1 Ce. | Normal. |0.1 Cc. | Excited. | 0.1 Cc. | Excited. | Depressed. Dead. Prep. 3./0.1 Ce. | Normal. |0.1 Ce. | Slightly | 0.1 Ce. | Depressed.|Very weak. Dead. depressed. Prep. 4.0.1 Ce. | Normal. | 0.1 Ce. | Depressed. | 0.1 Cc. | Depressed. |Very weak.| Nearly Dead. dead. EXPERIMENT 38. rare A Niemalt - F : = = = = = = a = < < a pa my < <t = my Ay g g S 2 s S g E s s = S a = S z S oi S = Prep. 1./0.1 Cc. |Normal} Normal |0.1 Ce. |Depress’d| Dead Prep. 2.) 0.1 Ce. |Iixcit’d| Excited | 0.1 Ce. | Excited | Nearly | 0.1 Ce. | Excited Dead Normal Prep. 3.) 0.1 Ce. |Normal| Slightly | 0.1 Ce. |Depress’d) Slightly | 0.1 Ce. Very Very .| Dead excited depressed depressed|depressed Prep. 4.| 0.1 Ce. |Normal) Normal | 0.1 Ce. |Depress’d| Normal | 0.1 Cc. /Depress’d|Depress’d} Slightly : depressed
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