The synthesis of histidine / by Frank Lee Pyman.

  • Pyman, Frank Lee.
Date:
[between 1900 and 1909?]
Catalogue details

Licence: In copyright

Credit: The synthesis of histidine / by Frank Lee Pyman. Source: Wellcome Collection.

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    ethylglyoxaline dipicrate, which formed yellow needles, melting at 201° (corr.), after drying at 100°: 0-1181* gave 0'1615 C02 and 0*0305 H20. 0=37*3; H = 29. C6HnN3,(C6H307N3)2i requires C=37’0; H = 2'9 per cent. The mother liquor from this salt then gave a small quantity of 1: 5-dimethylglyoxaline picrate in clusters of slender needles, melting at 167—168° (corr.): 0-0907 gave 0*1345 C02 and 0*0267 H20. C = 40-4; H = 3*3. C5H8N2,06H307N3 requires 0 = 40*6; Hj=3*4 per cent. This salt was identified by determination of the melting points of its mixtures with pure 1: 4- and 1 : 5-dimethylglyoxaline picrates (Trans., 1910, 97, 1819), when it was found that the mixture with the 1: 4-salt melted at 135—140°, whilst that with the 1: 5-salt still melted at 167—168° (corr.). The alcoholic extract gave a very sinall quantity of a crystalline picrate which melted at 162—175°; it was probably impure l-methylglyoxaline-5-acetic acid picrate, but the quantity obtained was insufficient for identification. The Wellcome Chemical Works, Dartford, Kent. * Dried at 1009. K. CLAY AND SONS, LTD., BRUNSWICK ST., STAMFORD ST., S.E., AND BUNGAY, SUFFOLK.