Report of investigations into the pathogeny of diphtheria / conducted by Edward Curtis and Thomas E. Satterthwaite.

  • Edward Curtis
Date:
[1877]
Catalogue details

Licence: Public Domain Mark

Credit: Report of investigations into the pathogeny of diphtheria / conducted by Edward Curtis and Thomas E. Satterthwaite. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

    51/56 page 51
    VI.—INOCULATIONS OF SALICYLIC ACID. a. Inoculation of muscular tissue with solid salicylic acid. Some of Squibb’s unbleached salicylic acid was mixed into a paste with water, and inocu- lated in the usual way. Experiment 125 : May 28, 1875. Both thighs of a rabbit inoculated with the paste of salicylic acid. June 4. Animal in excellent condition. Skin-wounds closed by scabs, without thick- ening. Left side : A depression felt over site of muscle-wound. Skin snipped, and parts explored. No sign whatever of any lesion in the connective-tissue. The hole made by the original muscle-wound remained as an excavation % inch in diameter, presenting a brown-colored surface. The material of this brown layer of tissue con- sisted of connective-tissue elements, blood-corpuscles, and muscular fibres in a state of unnatural stiffness, shrinkage, and brownish discoloration—an appearance similar to what is produced in muscle by the action of weak chromic acid. No sign of pus, or of irritation of tissues in the neighborhood of the muscle-wound. July 1. Skin and muscle-wounds completely healed. Animal in good condition. July 10. Animal in good condition. Experiment 126: May 28, 1875. Both thighs of a rabbit inoculated with the paste of salicylic acid. June 4. Skin of thighs snipped and parts explored. Appearances identical with those of foregoing experiment at same date. June 24. Animal well; nothing to be felt from without ; legs not explored. July 10. Animal in good condition. Experiment 127 : May 28. 1875. ' Both thighs of a rabbit inoculated with the paste of salicylic acid. June 4. Animal in excellent condition. No thickening to be felt, and on opening skin, no lesion in the neighborhood of the skin-wound. June 12. Animal in excellent health. b. Hypodermic injection of salicylic acid dissolved in aqueous solution of sodic phosphate. The rabbits used in this and the following series of experiments were all of the same litter ; small animals, weighing l'f pounds each. Experiment 128: March 12, 1875. Injected following solution : Salicylic acid, 5 grains ; sodic sulphate, 15 grains; water, 25 minims. For the following two hours animal somewhat stupid and quiet ; respirations quickened. No interference with any of the functions. March 13. Animal lively, apparently as well as ever.
    digitised image 1
    digitised image 2
    digitised image 3