The pharmacological assay of digitalis by different methods / by J.W. Trevan [and others].

  • Trevan, J. W. (John William)
Date:
[1928?]
Catalogue details

Licence: In copyright

Credit: The pharmacological assay of digitalis by different methods / by J.W. Trevan [and others]. Source: Wellcome Collection.

    5/20 page 9
    The activity of tinctures U and D determined in terms of tincture S is given for each experiment in Table 2. TABLE 2. Tinctures. Doses in c.c. per 100 gm. frog. Experiment. Three hours ratio. Overnight ratio. U and S 0-6 S and 0-4 U A 160-5% ? 0-5 S and 0-4 U 137 125 0-6 S and 0-3 U 186 ? 0-5 S and 0 3 U 159 166-7 0-4 S and 0 2 U B 138-8 156 0-3 S and 0'2 U f ? 0-4 S and 0-15 U 169 169 0-3 S and 0-15 U ? 1 04 S and 0 22 U C 195 181-8 D and S Of S and 0 7 D A 63-7 ? 0-5 S and 0-7 D 53-2 476 Of S and Of D 74-4 f Of S and Of D 62 53 5 04 S and If D B 45-9 48-8 0-3 S and 1-0 I) ? t 04 S and 0-8 D 55 3 54-3 0 3 S and 0 8 D ? t « 04 S and 0 85 D C ro i o 65-2 (N.B.—“ f ” indicates that the results could not be used because either none of the frogs, or all of them, died.) In this way a series of figures for the value of both D and U in terms of S was obtained. To obtain the final figure for the two tinctures it was clearly not sufficient to take the mean of the different results, for each of these depended for its accuracy on the number of animals employed in obtaining it. A final mean was obtained by multiplying each result by the number of animals used to obtain it, taking the sum of the products and dividing the sum by the total number of animals used. The figures obtained for D and for U appear in Table 3 (see page 10). The standard deviation of these results can be obtained approximately from the formula (Trevan4) : 180,000 p.q. K2
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