Further observations on the action of [beta]-iminazolylethylamine / by H.H. Dale and P.P. Laidlaw.

  • Dale, Henry Hallett, 1875-1968.
Date:
1911
Catalogue details

Licence: In copyright

Credit: Further observations on the action of [beta]-iminazolylethylamine / by H.H. Dale and P.P. Laidlaw. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    peptone is antagonistic to the vaso-constrictor action of adrenine, but not to that of barium chloride has been regarded by some writers as an index of its point of action. A similar antagonism can be observed in the case of £-L, the adrenine rise of pressure being much reduced during its action but not extinguished (Fig. 6) (cf. Pearce and Eisenbrey’s1 recent account of anaphylactic shock in the dog). But there is no obvious reason for regarding this partial antagonism to adrenine vaso- constriction as different from that produced by any other peripheral vaso-dilator. Instances of other plain-muscular organs are available in Fig. 6. Pithed cat. 1 mgm. /9-I. injected five mins, previously. Effect of injections, each of 0-05 mgm. adrenine, in order A, B, C, D, E. 5' between B and G, C and D, and D and E. which an augmentor effect of /3-I. may be antagonistic to an inhibitor effect of adrenine (non-pregnant uterus of cat or guinea-pig) and of others again in which both bases produce great augmentation of tonus (retractor penis of dog). We must conclude, therefore, that the vaso-dilator effect of /S-I. in the dog, cat and some other animals, is a primary action, peripheral in origin, independent of the integrity of the sympathetic neurones. Its failure to occur in the isolated perfused organ is still unexplained. 1 Joum. of Infect. Dis. vii. p. 575. 1910.
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