Physiological action of condurango / by T. Lauder Brunton.

  • Brunton, Thomas Lauder, Sir, 1844-1916.
Date:
[between 1870 and 1879?]
Catalogue details

Licence: Public Domain Mark

Credit: Physiological action of condurango / by T. Lauder Brunton. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    slight alterations compared with those which result from variations in food, and Toldt and Nowak have found that the amount of Nitrogen varies even in the flesh of the same animal, so that it would be almost necessary to analyze the flesh eaten every day as well as rigorously to fix its amount, and this would be more than anyone could well undertake who could not devote his whole time to the work. General Summary. Watery extract of Condurango has no action on frogs even when injected into the dorsal lymph-sac in doses of 5 grains. On rabbits it has no poisonous action when injected into the peritoneal cavity. When a solution containing fine particles in suspension is injected into the jugular vein the animal dies with symptoms of opisthotonos. When the coarser particles are removed this does not occur although the breathing is quickened. It is not improbable that the quickening of the breathing is due to the lodgments of fine particles in the pulmonary capillaries and that the opisthotonos which I noticed in one experiment (Exp. IX.) and which has been supposed by Granuzzi and Bufalini to be due to the direct action of Condurango on the nerve centres was really due to asphyxia caused by pulmonary embolism. Unlike quinine Condurango has very little effect on reflex action1. Condurango when injected into the peritoneum even in large doses has no action on the blood-pressure. It does not exert any definite action on the arterioles nor does it paralyze the peripheral terminations of the vagus.. 1 Since the preceding experiments were made Mr Pardington and I have found that the diminution in reflex excitability which Chaperon described as caused by the injection of quinine into the lymph-sac of the frog probably depends on the local irritation produced by the acid in which the quinine is dissolved.
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