Volume 1
History and pathology of vaccination / by Edgar M. Crookshank.
- Edgar Crookshank
- Date:
- 1889
Licence: Public Domain Mark
Credit: History and pathology of vaccination / by Edgar M. Crookshank. Source: Wellcome Collection.
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![and the ordinary results of a direct inoculation of Small-pox. In this case the appearances are strikingly dissimilar, but Adams selected a mild variety of Small-pox, called the pearl sort, and succeeded by cultiv^ation on the human subject in producing appearances indistinguishable from ordinary vaccination.—E.M.C.] Plate VIII. VARIOLATION OF THE COW. {CEELY)facingp. 298 Showing the progress of the variolation experiment on the fifteenth day. “ The variolous vesicle at its maximum of development with a large central crust; it had a florid glistening appearance. The vaccine vesicles of the seventh day were also at their greatest development, had slight central crust, and were surrounded, like the variolous vesicle, with a small pale areola.”—{Ceety.) The whole history of this experiment is as follows :— “ E.xpcriment first.—Red and white sturk, thin skin, gentle, well bred ;— Made seven punctures, and introduced fourteen points, charged half their length, near the left side of the vulva and below it. Inserted two setons, charged with Small-pox virus from the same subject, at the same time. Fifth Day.—Two or three of the punctures tumid, all closed with brown plugs ; setons tumid. “Sixth Day.—Some punctures tumid. “Seventh Day.— Less tumid. “ Eighth Day.—Still less so ; setons passive, dry, adherent. “ Ninth Day.—No material alteration, and therefore vaccinated on the right side of the vulva, in seven punctures, with fifth, sixth, and seventh day lymph, on fourteen points, from a young child ; and below the vulva, in four punctures, with eight points. “ Tenth day of variolation, second of vaccination : Some of the variolated punctures hard and elevated ; but one, near the margin of the vulva, has assumed the form and appearance of the vaccine vesicle; it is nearly circular, has an elevated margin, and a small crust in the depressed centre. By gently removing the central irregular crust, and careful|ly puncturing the cuticle from under which this appears to have exuded, lymph was obtained, and thirty-eight points were scantily charged in the course of an hour. Vaccinated punctures on the right side, rather red and elevated. “ Eleventh day of variolation, third day of vaccination : The circular indurated intumescence, forming the margin of the vesicle, somewhat flattened and diminished. Vaccine punctures more red, larger, and more elevated. Evening: more crust in the centre of the Small-pox vesicle; margin less elevated. Vaccine vesicles advancing. “ Twelfth day of variolation, fourth day of vaccination : Margin of the Small-pox vesicle more elevated and red ; central crust darker ; two of the other variolous punctures more tumid, but without lymph, still merely tubercular. Vaccinated punctures more tumid and inflamed. “ Thirteenth day of variolation, fifth day of vaccination : Small-pox vesicle more inflamed, nearly as florid as the mucous membrane of the vulva, which has lately assumed a bright rose colour. Every puncture made for the vaccine lymph (five days since) effectual, vesicles of different forms and sizes being now apparent. Charged some points from them. “ Fourteenth day of variolation, sixth of vaccination ; Small-pox vesicle](https://iiif.wellcomecollection.org/image/b29007446_0001_0022.jp2/full/800%2C/0/default.jpg)
