A report of microscopical & physiological researches into the nature of the agent or agents producing cholera / by T.R. Lewis and D.D. Cunningham.
- Timothy Richards Lewis
- Date:
- 1872
Licence: Public Domain Mark
Credit: A report of microscopical & physiological researches into the nature of the agent or agents producing cholera / by T.R. Lewis and D.D. Cunningham. Source: Wellcome Collection.
Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.
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![Experiment XIII.—A healthy pup was put under „ . .... . ... . chloroform, and three drachms of Material injected (fluid and ^ ’ , 90 J sediment). i hours old. choleraic material injected into the left femoral vein. The material consisted of the fluid and sediment of an evacuation thoroughly shaken up, and was in an active state of decomposition, the fluid being covered with a thick layer of bacteria, and the sediment consisting in greater part of amorphous matter with a few persistent red blood corpuscles. The injection was performed at 9 a. m., and the dog rapidly came out of the influence of the chloro- Death in about 15 hours. form. It died at midnight of the A few eeehymosed spots in jejunum and the ileum coated with reddish mucus. same day without having shown any choleraic symptoms. A post-mortem examination was performed at 8 A. m. of the following morning, 23 hours after the operation. The post- mortem rigidity was well marked. Post-mortem appearances. 'X']iere was n0 evidence of inflamma- tory action around the wound in the thigh, which appeared clean and healthy. On opening the abdomen, the cavity was found to he free of fluid, the surface of the small intes- tines appeared slightly roughened, but the parietal peri- toneum was perfectly smooth and glistening, and there was no evidence of inflammatory action present. The stomach was empty, and there were a few eeehymosed spots on the mucous membrane. The duodenum ap- peared healthy and contained a small quantity of bile-stained mucus. The mucous membrane was perfectly free of injection throughout the upper portion of the jejunum, but towards the lower extremity there was an eeehymosed patch three or four inches in length. The ileum contained an abundance of mucus of a peculiar reddish hue. The large intestine was also coated with abundant reddish mucus. The liver both on the surface and'throughout its sub- stance showed numerous small, light coloured spots about the size of small shot. There were no inflammatory rings around them ; after the specimen had been for 12 hours in a weak solution of spirit, these spots, where on the sur- face, appeared slightly prominent; but these prominences disappeared on exposure to the air, and slight depressions replaced them, appearing to indicate that they had been due to an abnormal absorption of fluid at these points. On mi- croscopic examination, the material composing these light Small nodules of disin- tegrated matter throughout the liver.](https://iiif.wellcomecollection.org/image/b22355510_0045.jp2/full/800%2C/0/default.jpg)
