Standards of the constituents of the urine and blood and the bearing of the metabolism of Bengalis on the problems of nutrition / by D. McCay.

  • McCay, David, 1873-
Date:
1908
Catalogue details

Licence: In copyright

Credit: Standards of the constituents of the urine and blood and the bearing of the metabolism of Bengalis on the problems of nutrition / by D. McCay. Source: Wellcome Collection.

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    Table VII. Serial No. Total concentra- tion of serum by Wright’s method. Chlorides of serum by Harvey- McKendrick method. Quinine Sulph given thnce daily. Total . concentration ] of serum by | Wright’s method. Chlorides of serum by Harvey-McKendrick method. Per cent. Per cent. Per cent. Per cent. I •875 728 2 •928 •73 3 i-o6 75 4 l‘OJ •763 Gr. V. •960 •724 1 | 4 •96 5 724 „ v. •914 •723 | | 4 •914. 723 „ V. ■863 705 Consecutive 1 | days from 4 •863 '705 „ x. 701 ■612 | !■ 8th August 1 1 1907. 4 701 •612 „ X. •876 •720 4 •876 720 „ X. 1’061 758 4 x'oi6 758 „ XX. 1'04 754 J 1 [Many more observations were made on the effects of quinine sulphate in health and the invariable result found was the immediate decrease in the salt concentration of the serum—a negative phase—followed by a return to the normal degree of salinity. The effect of quinine sulphate would therefore appear to be to lessen the resisting power of the red blood corpuscles to haemolysis ; and the larger the dose the more quickly this resisting power is reduced. The bearing of these results on the administration of large doses of quinine sulphate as a factor in the causation of haemoglobinuria is obvious and opens up a very interesting problem.] In Europeans the total salinity of the serum is *90 --*95 per cent. Many authorities, however, give a lower value. In the Bengali the figures vary from 1*05—1*09 per cent. Wherever there was any appearance of anaemia we always found the salinity increased, while, on the other hand, the healthier the individual looked the lower the salt concentration of the serum turned out to be. (>) McCay—Ind. Med. Gazette, February 1908.