Selected monographs.

Date:: 1888

Catalogue details

Licence: Public Domain Mark

Credit: Selected monographs. Source: Wellcome Collection.

118/440 (page 102)

of albuminuria without admixture of blood, in rabbits, as a result of the injection of the blood-serum of animals belong- ing to different species. To explain this we must assume, either that the albuminous substances of these kinds of serum more readily filter through the kidneys of rabbits than through those of the animals to which they belonged; or that extraneous serum of this kind induces serious derangements, with albuminuria as an accompaniment. Taking into con- sideration the effect, presently to be discussed, of the serum upon the blood-corpuscles of other animals, it must be admitted that the latter assumption is the more probable of the two. Nothing certain is yet known as to the effect produced by the injection into the blood of other soluble albuminous sub- stances, peptone chiefly excepted. J. Chr, Lehmann observed no albuminuria after injections of Lieberkiihn^s albuminate of soda, of solutions of syntonin, myosin, and fibrin, whereas Euneberg witnessed the occurrence of albuminuria after the injection of an albuminous substance, which he obtained by dissolving in soda casein precipitated from milk by means of acetic acid, but not when he injected pure milk or milk mixed with soda (93). The former fluid possessed great capacity for filtration, and the question arose whether the albuminous substances made use of by Lehmann were less adapted for that pi'ocess, for solubility alone is no measure of the capacity for filtration. The other albuminous substances, distinguished by^their capacity fo^: diffusion and filtration, with which we are acquainted, are peptone (probably also propeptone) and heemoglobin. No experiments in this direction have as yet been made with propeptone, but it may with certainty be assumed that its behaviour is the same with that of the other two substances, which, introduced in a state of solu- tion into the blood, are, in accordance with theory, readily excreted in consequence of the marked capacity for filtration which they possess. With regard to peptone we know that it may find its way into the blood by injection, or by the absorption of exudations in which it is contained (as in pleurisy, pneumonia, and rheumatic arthritis), and that peptonuria then makes its appearance. The same origin