Manufacture of new derivatives of lecithins.

  • Aktiengesellschaft für Anilinfabrikation
Date:
1905
Catalogue details

Licence: Public Domain Mark

Credit: Manufacture of new derivatives of lecithins. Source: Wellcome Collection.

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    2 N° 13,285.—A.D. 1904. Abel's Manufacture of New Derivatives of Lecithins. Dated this 4th day of March 1905. ABEL & IMRAY, Agents for the Applicant. 5 30lCenewfdtn“uves are of great value for medicinal purposes because they fears -sm;H otherwise, the products formed by the change of lecithin. dissolved for 10 Jr, rk-rrl or +n Arnrhioe these bromine derivatives, lecithin may De aissoiveu iuf instance in chloroform and treated with bromine, the mixture being preferably lent at ordinary temperatures by cooling; the proportion of bromine may be Varied accoXg to the kind of the commercial lecithin used For instance wHMn derivedSfrom the yolk of eggs absorbs until the bromo-lecithm formed contains about £™JcJ of bromine. Within the limits of bromine which 15 the lecithin under treatment can absorb, the proportion of bromine may be varied as desired in every case. Example : Ten narts of lecithin are dissolved at ordinary temperature in 40 parts of chloroform this solution is mixed with 2.6 parts of bromine dissolved m 6 par 20 of chloroform, the vessel being cooled externally so that the temperature sh 11 not exceed 10—20° C. Ail the bromine having been lntioducecL mass is allowed to stand for a short time; it is then filtered and the fi ra evauorated in a vacuum at ordinary temperature or with gentle heating. I order to expel the last portion of chloroform, if the evaporation under diminished 25 pressure Sf not effected this, some absolute alcohol is added and the mass a^ain exposed to diminished pressure till it is absolutely dry. gIn thisPway there is obtained a nearly colourless mass resembling wax, soluble in chloroform, alcohol and ether, sparely soluble in acetone hardly soluble in water; it is easily saponified when heated with alcoholic soda-lye Du. bromo lecithin has no distinct melting point; when heated it softens, above 100 C. t melts and is decomposed. The incorporated proportion of bromine is about '^(bTcourse the invention is not limited to the above example nor to the details given therein. As already stated the different kinds of lecithin shew a different capacity for absorbing bromine and so the different commercial lecithins will shew some difference with respect to their being incorporated with bromine. But within the maximum of bromine that can be absorbed, various percen¬ tages of bromine may be incorporated so that for instance bromo-lecithm con¬ taining 5 per cent, 10 per cent or 15 per cent of bromine may be manufactured according to the present invention. Furthermore the result of the processi not materially changed if the treatment with bromine is carried out without the addition of a solvent. Having now particularly described and ascertained the nature of iny said invention and in what manner the same is to he performed, I declare that 45 what I claim is; — 1. The herein described manufacture of new derivatives of lecithins by treat¬ ing a lecithin with bromine. 2. The new bromo-lecithins manufactured as above set forth. 30 35 40 50 Bedhill: Printed for His Majesty's Stationery Office, by Love & Malcomson, Ltd.—1905.
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