The cinchona barks : pharmacognostically considered / by Friedrich A. Flückiger ; translated from the original text, with some additional notes, by Frederick B. Power.

  • Flückiger, Friedrich A. (Friedrich August), 1828-1894.
Date:
1884
Catalogue details

Licence: Public Domain Mark

Credit: The cinchona barks : pharmacognostically considered / by Friedrich A. Flückiger ; translated from the original text, with some additional notes, by Frederick B. Power. Source: Wellcome Collection.

    70/132 (page 64)
    The Cinchona barks contain, furthermore, in smaller amounts: Homocinchonidine, discovered by Hesse, in 1877 . . . . C Cinchonamine, obtained in 1881 by Arnaud, from Remijia Purdieana (p. 54)^ Homoquinine, found in 1882 by D. Howard and other English investigators, in Cinchona cuprea C Quinamine, discovered by Hesse, in 1872 Q Conquinamine, “ “ *' 1877 Cinchamidine, “ “ 1881 C ,H22N20 ,h24n2o a h 2 2 2 ^ 1 n2o . h24 of the Name coin Position. 20^26^2^ Ouinine and cinchonine stand at the head of two groups of alkaloids, which, indeed, individually, show quite broad distinctions, but present, however, with regard to their physiological action,1 some agreement. From these distinctive cinchona alkaloids the following bases are very considerably separated in every respect: Aricine, discovered by Pelletier and Coriol, in 1829,2 and analyzed by Hesse, in 1876 Cusconine, discovered by Hesse,3 in 1877 Cusconidine, “ “ “ “ 1877 Cuscamine, “ “ “ “ 1880 Cuscamidine, “ “ “ “ 1880 Paytine4, “ “ “ “ 1870 Paricine, in the bark from Para, mentioned on pages 58 and 68, discovered by Winckler, in 1845 c23h26n20 of the Harne composiiion. Inot yet analyzed. c21h24n20 nnt yet analyzed. 4 With the exception of paricine, cusconidine, and cuscamidine, the above named alkaloids are crystallizable. Besides the former, there occur however, other amorphous basess in Cinchona barks, the knowledge of which is still but slightly satisfactory. They are perhaps first formed, in part, from the crystallizable alkaloids, in the process of manufacture. The chinoidm of the manu facto ries consists, for the most part, of amorphous bases. Hesse6 isolated from the mother liquids of Cinchona barks, obtained from the manufactories, the slightly odorous cincholine, a base volatilizable with aqueous vapor, but which, however, may 1 It is only in the case of quinine that this has been satisfactorily determined from a medical standpoint. 2 In a bark of unknown botanical origin, which was exported a few times from Arica (see p. 32), and which may possibly belong to a Cinchona. 3 From barks which have not been botanically determined; the name relates to Cusco, in Southern Peru. Hesse, Berichte der Deutsch. Chem. Ges., 1883, pp. 58-63, announces the prcsence of two new alkaloids in a variety of cuprea” bark, viz: concusconine and concusconidine, both having the composition C23H26N204 ; and the list appears notyetcompleted. (F. B. P.) 4 In a so-called white Cinchona bark, which was once exported from Payta, the most northerly port of Peru, but is not to be met with in commerce. Compare, regarding the same, Fliickiger, Jahresbericht der Pharm., 1872, p. 132; also section 18, No. 35, of this work. 5 Every Cinchona bark contains amorphous alkaloids. Bernelot Moens, in 1881, States that their quantity varied from 0.13 to 1.45 per cent., as ascertained from 85 analyses performed by him. c Berichte der Deutschen Chemischen Gesellschaft, 1882, p. 858.