A peculiar form of hereditary congenital cataract / by E. Nettleship and F. Menteith Ogilvie.

  • Edward Nettleship
Date:
[1906?]
Catalogue details

Licence: In copyright

Credit: A peculiar form of hereditary congenital cataract / by E. Nettleship and F. Menteith Ogilvie. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    cataract, being sometimes normal and seldom less than unless from coincident refractive error. There is generally a dislike of bright light, shown by the habit of shading the eyes with the hand when the patient wants to see as well as possible. But, as already mentioned, the inconvenience is so slight that several in whom Mr. Ogilvie found the typical opacity refinsed to believe that their eyes were not quite perfect. Of the 288 pei-sons included in ]\Ir. Ogilvie’s and the Vicar’s pedigrees together, 131 were male, 115 female, and in forty-two the sex is not noted; a few of these cannot be correctly placed, and are therefoi-e omitted from Fig. 25 (Part B). A certain number of others, known but not actually identified, would bring the total to 300 or more. The cataractous branch alone (A, Fig. 25), contains 134 ])er.sons—seventy-one male, fifty-seven female, and six wlio.se sex is not given; the cousin-husbands belonging to the non-cataractous division are not counted. Of the 134 thirty-three are dead, and of the remaining 101 ninety have been examined, with few exceptions by Mr. Ogilvie himself, viz., forty-four nnales, forty females, and six sex 7iot stated. In sixteen of the ninety, seven males and nine females, the peculiar family cataract has been found. It is nearly certain that two others, males (Generation IV, 2 and 3) now dead, were affected, for both of them are known to have always had somewhat imperfect sight and the habit of shading their eyes; this brings the total to eiarhteen—nine of each sex. The descent of the cataract was continuous in every instance—once through four generations (IV, 3 to V, 9 to VI, 31 to VII, 8) ; once through three generations (IV, 3 to V, 11 to VI, 38, etc.) ; twice through two generations (IV, 6 to V, 25, and IV, 10 to V, 26, etc.). Transmission was by the father four times, by the mother thrice, the four fathers having twenty-two children, of whom eight were affected, the three mothers twelve children, of whom five were affected. Descent being, so far as we know, always continuous
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