Some new gold salts of hyoscine, hyoscyamine and atropine / by H.A.D. Jowett.

  • Jowett, H. A. D. (Hooper Albert Dickinson)
Date:
[1897.]
Catalogue details

Licence: Public Domain Mark

Credit: Some new gold salts of hyoscine, hyoscyamine and atropine / by H.A.D. Jowett. Source: Wellcome Collection.

    3/8
    Some New Gold Salts of Hyoscine, Hyoscyamine, and Atropine. By Hooper Albert Dickinson Jowett, D.Sc. In the course of some work necessitating the preparation of the aurichloride from the hyoscine hydrobromide of commerce (which, it may be remarked, is really scopolamine hydrobromide), it was observed that, on mixing aqueous solutions of this salt with auric chloride, a red precipitate was formed instead of the characteristic yellow aurichloride. Experiments made to determine the composition of this precipitate showed that it is an additive compound of gold chloride with the hydrobromide, and may thus be termed hyoscine hydrobromide gold chloride [B,HBr,AuClg] In studying the conditions of formation of this salt, the auribromide [B,HBr, AuBr3] was also prepared, and it was further observed that the other solanaceous alkaloids, atropine and hyoscyamine, react in a similar manner, forming analogous com¬ pounds. ffyoscine hydrobroffiide gold chloride^ C.^H^.NO^jHBqAuClj, is formed when aqueous solutions of hyoscine hydrobromide and auric chloride are mixed either in equivalent proportions or with a slight excess of auric chloride, the red, amorphous ])recipitate which is formed becoming crystalline on standing, or, better, by heating the mixture to boiling and then cooling, when a croj) of dark red, prismatic crystals separate, d'he salt is best recrystallised from boiling water acidified with a little hydrochloric acid, when it sej^arates in red prisms which melt and decompose at about 215'’. d'he salt is soluble in boiling