Drug eruptions : a clinical study of the irritant effects of drugs upon the skin.

  • Morrow, Prince A. (Prince Albert), 1846-1913.
Date:
1887
Catalogue details

Licence: Public Domain Mark

Credit: Drug eruptions : a clinical study of the irritant effects of drugs upon the skin. Source: Wellcome Collection.

Provider: This material has been provided by The University of Leeds Library. The original may be consulted at The University of Leeds Library.

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    thema, always limited to the lower extremities, accompa- nied by high fever, and quite painful. According to other observers, it may occur as a bright-red or dusky-red rash, in patches the size of a finger-nail or a pea, and not absolutely confined to the lower extremities. Bedford-Brown has no- ticed the occurrence of a roseola from bromide of potas- sium in children. Comparatively few observations of this nature have been recorded, probably because this drug is seldom administered to children, and not because they are insusceptible to its pathogenetic effects. Carlos reports a case in the service of M. Voisin in which bromide of am- monium produced an eruption of slightly elevated patches of a vivid red color^ with subcutaneous induration. The eruption first appeared on the thighs and abdomen, and beca.me general. It disappeared with considerable desqua- mation. TJie Urticarial Form.—Voisinob served in two cases, out of ninety-six upon which his studies were based, an erup- tion, preceded by pain and pruritus, of oblong or irregu- larly rounded elevations of the skin of varying size, from one-fifth to two and one-half inches in diameter, and of a rose-red or cherry color. They presented the shape, color, and hard base of erj^thema nodosum, but resembled urti- caria in reappearing when rubbed. These lesions per- sisted so long as the bromide was given, but they rapidly disappeared on the discontinuance of the drug, always leaving behind the subcutaneous nodosities which were slower in evolution. Veiel also observed coin-shaped, wheal-like elevations, varying in size from one-quarter to one-half inch in diameter, develop on erythematous patches of skin, but only upon the legs. They were very sensitive to the touch, and, if the drug was continued, they took on a suppurative action. Richard, cited by Deschamps, re- ports the occurrence] of an eruption developed upon