Chemistry of the proteids / by Gustav Mann ; based on Professor Otto Cohnheim's 'Chemie der eiweisskörper.'.

  • Gustav Mann
Date:
1906
Catalogue details

Licence: In copyright

Credit: Chemistry of the proteids / by Gustav Mann ; based on Professor Otto Cohnheim's 'Chemie der eiweisskörper.'. Source: Wellcome Collection.

    18/638
    iiidol-amiiio-])ro))ioiiic acid, 51; diacipiperazin-coni}iounds, 55; ammonia, 55; cystiu, 56. Stereo-cliemistry of amino-acids, 64. Quantitative composition of albumins, 65. Tables of percentage-com])Osition, 70-75. Nitrogen radicals of the albumin-molecule, 76-82. Halogen-substituted albumins, 82. Unclassified dissociation-products, 82 : amino-butyric, tliiolactic, pyro-uvic, and dianiino-acetic acids, 83 ; glucosamin, 83 ; galactosamin, 84 ; kyn- urenic acid, 84; skatosin, lysatinin, leucin-imide, 85; prussic acid, 86. Humin substances, 87-90. Secondary dissociation-products derived from the amino-acids, 90-114 ; dis- integration by boiling alkalies, 90, by superheated steam and oxidising media, 92; by acids, 94-96 (treatment with acids with subsequent reduction, 94 ; vuth nitric acid, 94 ; with nitrous acid, 95) ; by bromine, 96 ; by sulphur, 97 ; by enzymes, 98-114 ; general remarks, 98-100 ; by bacteria, 100 ; by non-baeterial plants during metabolism, 104 ; by animals, 106 ; desamination, 112. CHAPTEE III Synthesis of Albumins ...... Early researches by Schaal, Schitf, Grimaux, and Theodor Curtins. Use of acid chloride by Curtius, 115; biuret-base, glycyl-glycin, 116; reactions of the biuret-base, 117 ; benzoyl-compounds prepared by Curtius, 118 ; employment of acid-anhydrides, 118, and of acid-azides, 119; succinyl- glycocoll, adipinylgiycin, benzoyl-penta-glycylglycin or 7-acid, hexa- glycylglycinester, 120; hippuryldialanyl-alanin, benzoyl-alanin, benzoyl- alanyl - glycyl - glycin, hippuryl - aspartic acid, hippuryl - asparagyl- aspartic acid, 121; hippuryl-diasparagyl-aspartic acid (colloidal nature of peptids), hii3puryl-a-oxy-/3-amino-propionic acid, liippuryl-/3-amino- butyric acid, hippuryl -- phenyl - a - alanin, 122 ; phenyl - carbamin- diglycyl-glycin, dissociation-products of hij)pur-azide-compounds, 123. Summary by Curtius, 124. Synthesis by Schiitzenberger, Balbiano and Frasciatti, 124, and Lilienfeld, 125. Emil Fischer’s work, 125-138 ; eonversion of diacipiperazin or diglycocoll- anhydride into the open-chain glycyl-glycin, 126 ; alanyl-alanin- leucyl-leucin-dipeptids, 127 ; normal glycocoll-alanin anhydride, 127 ; introduction of carboxethyl-radical into NH.^ group, and union of carbethoxyl-amiiio-acid-ester with other amino-acid-esters by gentle heat, carbethoxyl-glycyl-glycyl-leucin-ester; use of thioiiyl-chloride for converting carbethoxy-compounds into their ehlorides, carbethoxy- glycyl-glycin,—diglycylglycin, and triglycyl-glycin-esters, 128; trigly- cyl-glycin-dicarboxylie acid, carbethoxy-triglycyl-glycin-amide, 129; carbamino-glycyl-glycin-ester ; use of /3-naphthalinsulphonic acid for separating dipeptids, 129 ; linking amino-acids by their NH2-end by introducing -halogen-containing acid-chloride radicals (chlorides of chloracetyl, brompropionyl, a-brom-iso-capronyl, a-5-di-bromvaleryl, phenyl - a - brompropionyl), methyl - diacipiperazin, 129; chloracetyl- glycyl-glycin and diglycyl-glycin. Definition of term peptid. Tetra- glycyl-glycin. Introduction of chlorine into both NHo and COOH- groui)s. Hippuryl-chloride, benzoyl-glycyl-glycin, benzoyl-diglycin- PAOE 115