Gout : its pathology and treatment / by Arthur P. Luff.

  • Arthur P. Luff
Date:
1898
Catalogue details

Licence: Public Domain Mark

Credit: Gout : its pathology and treatment / by Arthur P. Luff. Source: Wellcome Collection.

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    and serpents is composed of an amorphous quadri- urate, and that in the amorphous condition it is incapable of acting as an irritant. Moreover, it is possible, as Sir William Roberts has suggested, that the uratic excrement passes through the tubules of the kidneys of birds and reptiles in the gelatinous form, which could not produce the mechanical irritation that a crystalline deposit would be liable to cause. 2. The uric acid compound regarded as acting as a poison or irritant while in the dissolved state.—This view, while holding that the uric acid compound is the primary cause of gout, regards it as producing morbid changes in the structure of tissues while remaining in the dis- solved state. Many writers and observers have supported the view that, apart from the local trouble in the joints caused by the deposited sodium biurate acting as an irritant, the soluble uric acid compound which is circulating in the muds of the body acts as a poison, the toxic effects of which are responsible for a number of the symptoms associated with the gouty state. Pfeiffer holds the somewhat peculiar view that a compound of uric acid is deposited in both healthy and diseased portions of the body— apparently without producing any marked symptoms—and that an acute attack of gout is caused by the blood re-dissolving this deposited uric acid compound, owing to a temporary increase in the alkalinity of the blood, and that dissolved in the blood in this concentrated form the uric
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