Gout : its pathology and treatment / by Arthur P. Luff.

  • Arthur P. Luff
Date:
1898
Catalogue details

Licence: Public Domain Mark

Credit: Gout : its pathology and treatment / by Arthur P. Luff. Source: Wellcome Collection.

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    effect which he believes constitutes the primary cause of gout. His view is that the graver mani- festations of gout only make their appearance when the functions of the kidneys become im- paired from any cause, and since he finds that in the urine of the gouty there is an increase of alloxuric substances, and also that alloxur bases cause changes in the kidneys resembling parenchy- matous degeneration, he infers that these bases are concerned in the production of the kidney affection which precedes the development of gout. His theory is that during normal action of the kidneys the greater part of the alloxur bases is excreted as uric acid; but when the structures which form uric acid are enfeebled there is an increased excretion of alloxur bases, with con- comitant toxic effects. Kolisch's views have re- ceived some confirmation by Weintrand, * who has also found an excessive excretion of alloxuric substances in the urine of gouty patients. On the other hand, they are controverted by the observa- tions of Schmoll.t His,t Laquer,§ and Mafatti,|| who failed to find any increased excretion of alloxuric substances in the urines of gouty patients. II.—Morbid changes in the structure of TISSUES REGARDED AS THE PRIMARY CAUSE OF GOUT. This group may be divided into two sections * Charite Annalen, 1895, xx., p. 215. t Zcitschrifi fur klinische Medicin, 1896, xxix., p. 510. % Berliner klinische Wochenschrift, 1896, xxxiii., p. 70. § Verhandlungen des Cong.f. innere Med., 1896, xiv., p. 33. . || Wiener klinische Wochenschrift, 1896, ix., p. 723.