Gout : its pathology and treatment / by Arthur P. Luff.

  • Arthur P. Luff
Date:
1898
Catalogue details

Licence: Public Domain Mark

Credit: Gout : its pathology and treatment / by Arthur P. Luff. Source: Wellcome Collection.

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    cells, is set up in the neighbourhood of these necrotic areas. CRITICISM OF EBSTEIN'S EXPERIMENTS ON BIRDS. This class of experiments therefore consisted of observations of the uratic deposits formed in fowls when the elimination of their uric acid is prevented either by ligaturing the ureters, or by the pro- gressive disablement of the kidneys by repeated subcutaneous injections of potassium chromate. i do not think that the morbid processes occurring under these conditions in fowls can be considered as, in any sense, comparable with those occurring in connection with gout in man. Ebstein found uratic deposits in the liver and muscular tissues of the birds experimented on, localities where they are not found, at all events to any appreciable extent, in human gout. From this one may fairly conclude that the two processes cannot be con- sidered as comparable. Moreover, since the fowl produces and eliminates by the kidneys so large a quantity of urates, the more or less sudden stoppage of kidney excretion must necessarily result in the damming back of it and the rapid accumulation of it in the blood and tissues, where, as Sir William Roberts * suggests, it would probably first collect in a state of solution as the quadriurate, which would then bo precipitated in the tissues as the gelatinous biurate, and this in its turn would be changed into the crystalline biurate. * Croonian Lectures: Uric Acid Gravel and Gout,' 1802, p. 118.