Gout : its pathology and treatment / by Arthur P. Luff.

  • Arthur P. Luff
Date:
1898
Catalogue details

Licence: Public Domain Mark

Credit: Gout : its pathology and treatment / by Arthur P. Luff. Source: Wellcome Collection.

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    instead of going on to the complete stage of urea formation. Charcot regarded the liver as the principal seat of production of uric acid. He considered that a functional derangement of the liver caused the production of excessive quantities of uric acid, and its consequent accumulation in the blood. Meissner regards the liver of fowls in the normal condition as the principal source of uric acid, but considers that the spleen and the nervous tissues share in the formation. Ranke was of opinion that his experiments led to the conclusion that the spleen was the principal organ concerned in the production of uric acid. It has, however, never been possible to show that the spleen takes any active part in developing gout. On the con- trary, the large amount of uric acid found in the blood of cases of leucocythsemia and severe anosmia show that an exaggerated production of uric acid does not by itself exert any influence on the origin of gout. VIEWS THAT URIC ACID IS PRODUCED IN VARIOUS TISSUES. Ebstein, who attributes in cases or gout the main production of uric acid to the muscles and bone-marrow of the affected extremities, admits, however, that the kidneys may take a part, not only in the secretion, but also in the manufacture of uric acid. Robins was the first to formulate the view that uric acid is formed in connective tissues generally, and that the patho- logical condition is merely an exaggeration of the