Gout : its pathology and treatment / by Arthur P. Luff.

  • Arthur P. Luff
Date:
1898
Catalogue details

Licence: Public Domain Mark

Credit: Gout : its pathology and treatment / by Arthur P. Luff. Source: Wellcome Collection.

    72/272 page 60
    patients a well-marked diminution of uric acid in the urine occurred. It was also noticed that after the lead had been given for a day or two, the excretion of the uric acid in the urine was suddenly diminished to a very small amount—a condition which usually lasted for a day or two. This points to the fact that lead exercises a marked inhibitory effect on the cells of the kidneys concerned in the excretion of uric acid. The action of the lead is not due to inhibition of the formation of uric acid, since in cases of plumbism the blood becomes charged with uric acid. Alcohol is another body which in excessive quantities gives rise to kidney mischief, and which may also give rise to gout. REASONS FOR BELIEF IN THE RENAL ORIGIN OF GOUT. There is abundant evidence to show the connection between kidney mischief and gout for the following reasons :—(1) Uric acid has, in every case in which it has been specially searched for, been found in the blood of cases of renal disease; (2) uratic deposits are fairly frequently found in the joints of persons who have suffered from renal disease, but who have never been known to have had ostensible gout; (3) kidney mischief is fre- quently met with at the post-mortem examinations of gouty subjects; and (4) certain toxic agents predispose to both kidney disease and gout. The statement has been made that the absence of ostensible gout in those cases of kidney disease
    digitised image 1
    digitised image 2
    digitised image 3