Gout : its pathology and treatment / by Arthur P. Luff.

  • Arthur P. Luff
Date:
1898
Catalogue details

Licence: Public Domain Mark

Credit: Gout : its pathology and treatment / by Arthur P. Luff. Source: Wellcome Collection.

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    while urea is always present in the blood. The blood of the renal artery is much richer in urea than the blood of the renal vein: according to Picard in the proportion of about two to one, according to Sir Alfred Garrod in the proportion of about three to one. From his most recent •observations, Sir Alfred Garrod * concludes that in birds and other uric acid-excreting animals the metabolism of the nitrogenised tissues is exactly the same as in mammals. He believes that urea is the ultimate product of this metabolism, and that the uric acid is a subsequent product of the union of urea with some other principle or prin- ciples, glycocine probably being one of them. He regards the kidney as the organ whose function it is to manufacture uric acid from the nitrogenised matters brought to it in the blood, and considers it possible that the kidney contains different cells— some for the formation of urea, and some for the formation of uric acid—and that the ratio between the two may vary in different classes of animals. One very strong argument against the forma- tion of uric acid in the liver, spleen, connective tissues, etc.; is that it is never present in the blood of mammals (including man) and of birds in health. If it were formed in such organs or tissues, it must be conveyed in the blood to the kidneys. Since, according to Sir Alfred Garrod's and my own investigations, urea, and not uric acid, is found in the blood ot birds, and since uric acid, and not urea, is found in the urinary excrement of birds, it * 'Proceedings of the Royal Society, 1893.
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