Further studies of experimental nephritis : some effects of diuretics / by Henry A. Christian, M.D., Boston.

  • Henry Asbury Christian
Date:
[1913?]
Catalogue details

Licence: In copyright

Credit: Further studies of experimental nephritis : some effects of diuretics / by Henry A. Christian, M.D., Boston. Source: Wellcome Collection.

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    the rabbits twice a day in doses, with few exceptions, equivale; per kilo of body weight to those employed therapeutically in ma A severe, usually quickly fatal nephritis was produced and t. effect of the diuretic was measured by the length of life of t] animals compared with control animals that had received the sar dose of uranium nitrate; all animals were kept under the same cos ditions in large pens, with free access to water and a food supp of carrots and hay. The amount they ate and drank depended < their appetite, and varied much with variations in their conditio! One hundred and thirty rabbits were used. In addition to these number of normal rabbits received the same diuretic drugs over longer period of time as controls to exclude any marked toxici of the diuretic drugs. It was found that diuretic drugs in rabbits with severe acul uranium nitrate nephritis had a detrimental effect in that th< shortened the lives of the animals. With diuretin given by stoma* tube (in some of these animals the doses were much larger tin the usual therapeutic dose for man), rabbits with nephritis liv< six days while controls lived 6.9 days. When the diuretin w given intravenously they lived four and one-fifth days whi* controls lived six and one-fourth days. With caffein, solufc theocin (theocin sodium acetate), potassium acetate and sparte* sulphate given intravenously the average length of life was frv four and four-sevenths, four and four-sevenths, and six days respe tively while controls lived eight and one-fifth days. As all the dru were dissolved in water so that the dose per kilo of body weig! was contained in 4 c.c. of sterile water, a considerable amoui of water was introduced per diem intravenously in the rabbit Hence, to determine any influence of the water in a small numb; of nephritic rabbits water alone was given intravenously. The lived an average of five and one-sixth days while of controls tv survived and two lived an average of five days. In all experimens control rabbits were selected at random from stock pens at tl same time the rabbits to receive diuretics were chosen. In another series of twenty-one rabbits more accurate metabolis studies were made. These rabbits were kept in metabolism cage;- their food (oats and carrots) and water intake and urine outpi? were measured. Their non-proteid and urea nitrogen in the bloc