Cinchonine : C[20]H[12]NO / by Joseph Ince.

  • Ince, Joseph.
Date:
1863
Catalogue details

Licence: Public Domain Mark

Credit: Cinchonine : C[20]H[12]NO / by Joseph Ince. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    Though the concluding sentence may be most honourably meant:— With regard to the extraction of these two bases, faithful to our plan Quant a I'extraetion de ces deux bases, fidele a notre systeme de n'avoir aucun medicament secret, et de faire toujours part a nos confreres des resultats de nos recherches, nous en avons donne le procede dans notre memoire lu a I'Academie des Sciences; on pent y avoir recours. of having no secret remedy, and of always communicating the result of our researches to our bretkren, we have given the process in our memoir readbeforethe Academie des Sciences, which may be consulted. I make these remarks the more willingly at the present time, as a most ele- gant and inexpensive salt of Cinchonine is before the public,—the Muriate of Cinchonine,—which may be obtained through the usual commercial chan- nels ; it has the decided advantage of being very soluble in water, as well as being attractive in appearance. I see no reason, though laboratory difl&culties seem to oppose, why an equally soluble Sulphate of Cinchonine should not foUow in its wake. The best authoritj'^ (Pelletier) declares, L'acide sulfuri- que s'unit a la cinchonine, et forme avec cette base un sel neutre tres-soluble : ce sel pent s'obtenir facilement cristallise. Again, Merat calls it le sul- fate de cinchonine, qui est tres-soluble dans I'eau. MeanwhUe we must rest satisfied with the Muriate, and the following pre- parations naturally suggest themselves to the pharmaceutist:— Tinctura Cinchouiap Conip. H. Cinchouiae Muriat. 5v 9j ; Tinct. Aurant. 2 pints. M. None would probably be sorry to see the Tinct. Quinse Comp. of the pre- sent Pharmacopoeia omitted on account of the great difficulty of effecting the solution of the Quinine. Mr. Squire says, I find by experiment, that in seven days, 39-40ths were dissolved, but the weather, or rather the temperature, has an unfortunate influence in modifying this result; by substi- tuting the Cinchonia salt, the embarrassment disappears. Solution of Cinchonine. E. Cinchonise Muriat. 5j ; Aquse destillat. 3] ; Tr. Aurant. ad 5xx. 01. Ciunani. 9j ; Sp. rectif 3ss. Dissolve the Muriate of Cinchonine in the water, add the solution to the tmcture, to which add the Oil of Cinnamon previously dissolved in the spirit, fibber. A strong solution of cinchonine (three grains to a drachm) is thus effected, the oil of cinnamon effectually masking the bitterness of the prepara- tion. It IS right to state that Briquet estimates the strength of Cinchonia at one- third less than that of Quina; and Howard estimates the strength of the Muriate of Cinchonine at one-fifth less than that of the Disulphate of Quina. Both statements are open to a doubt. Syrup of Cinchonine. E. Ciuchonise Muriat. gr. xxiv; Aq. destillat. 5j ; Syrup. Simpl. a^aj. M. This syrup contains three grains in each drachm. Whilst on this point.