Experiments to investigate the infectivity of Glossina palpalis fed on sleeping sickness patients under treatment / by Sir David Bruce [and others].
- Date:
- [1911]
Licence: Public Domain Mark
Credit: Experiments to investigate the infectivity of Glossina palpalis fed on sleeping sickness patients under treatment / by Sir David Bruce [and others]. Source: Wellcome Collection.
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![Class A.—Those who are apparently in good health: gland enlargement with trypanosomes present in the glands. Class B.—Those in whom there are early signs from which the existence of Sleeping Sickness may be reasonably suspected. Class C.*—Those in whom clinical signs are well marked. Class D.*—Advanced cases. These experiments were carried out from January to March, 1910. Of the 33 patients under observation, | | 6 belonged to Class A. 19 ” ” ley 7 ) ” Oh 1 ”? ” iB) The methods adopted to test the degree of infectivity of patients to the fly in different stages of the disease were: (1) By mechanical transmission from Sleeping Sickness patient to normal monkey, and (2) by transmission of the disease from Sleeping Sickness patient to normal monkey after the parasite had completed its development in the fly. 1. By Mechanical Transmission from Sleeping Sickness Patient to Normal Monkey. The procedure in testing the first method was as follows:—A cage of laboratory-bred flies was first placed for two minutes upon the bare shoulders of a patient suffermg from Sleeping Sickness, which was time enough to allow the majority of the flies to draw some blood, but not enough to satisfy them. After an interval of five minutes the cage was transferred to the abdomen of a normal monkey, where it remained for two minutes, by which time nearly all the flies had completed their feed. This procedure was repeated daily for six days. Ten of the patients under experiment had been treated with soamin and perchloride of mereury administered by subcutaneous injection. Two patients, who had been under treatment for one year, had received several] doses of atoxyl, in addition to soamin and mercury. Trypanosomes had been found at one time in the glands of all the patients, but no trypanosomes were found in their blood during the time the flies were being fed upon them. * Classes C and D are not now differentiated.](https://iiif.wellcomecollection.org/image/b3343282x_0004.jp2/full/800%2C/0/default.jpg)
