Experiments to investigate the infectivity of Glossina palpalis fed on sleeping sickness patients under treatment / by Sir David Bruce [and others].

Date:
[1911]
Catalogue details

Licence: Public Domain Mark

Credit: Experiments to investigate the infectivity of Glossina palpalis fed on sleeping sickness patients under treatment / by Sir David Bruce [and others]. Source: Wellcome Collection.

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    Table I—Transmission of 7rypanosoma gambiense from Sleeping Sickness Patients to Healthy Monkeys by Interrupted Feeding. No. of yee If Duration N No. No. of experl- of pane Ween of of ae of flies | times flies Result. ment. P ; | treatment. if fed. fed. 2014 A | —¥es 7 days 2 75 6 = 2137 pe : ee 2 65 7 she 2144 C | fs hy or ae 75 6 —_ 2146 B i ipa 2 65 6 - 2013 A . sce | 4 75 6 = 2027 B ; oe 4 75 6 es 2029 B ‘ Sr, 4 75 6 Be 2150 Cc i 30: ,, 4 70 7 = 2152 C ‘ ae 4 50 7 ae 2158 B a 30, 4 60 6 = 2139 B i. 1 year ? 70 6 - 2154 B ‘ ae 2 50 6 = 2012 B No Nil Nil 75 6 - 2281 B ? ‘ re 100 6 <2 2284 B bi #6 i, 50 6 - Remarks.—These experiments are all negative—a not unexpected result now that it is known that the mechanical transmission of Sleeping Sickness may be a somewhat rare event in Nature. The question as to whether the medicinal treatment of Sleeping Sickness patients has any preventive influence on this method of transmission remains unanswered. It may, however, be noted that in the two untreated cases, viz., Experiment 2281, Class B, and Experiment 2284, Class B, the disease was not transmitted mechanically, but, as will be seen later (Table ITI, Experiments 2280 and 2298), was conveyed after a period of development of the parasite within the fly. 2. By Transmission of the Disease from Sleeping Sickness Patient to Normal Monkey after the Parasite had Completed its Development in the Fly. The procedure adopted in the second method for transmitting the disease from a Sleeping Sickness patient to a monkey was as follows:—A cage of laboratory-bred flies was fed daily for five or six days upon a patient suffering from Sleeping Sickness. They were then starved for 48 hours, and subsequently fed daily for 50 days upon a normal monkey. In most of these experiments the flies were dissected and examined for flagellates after the period of feeding upon the normal monkey. The monkey’s blood was subsequently examined twice weekly for one month after the last date on which the flies were fed upon it. Trypanosomes had been found at one time in the glands of all these patients, but no trypanosomes were found in their blood during the time the flies were being fed upon them. In the following tables all the details bearing on each class of patient are given :—
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